Anticholinergic agent

This page covers all Anticholinergic agent drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Muscarinic acetylcholine receptors (M1, M3, M5), Muscarinic acetylcholine receptor (M1), Muscarinic acetylcholine receptors (M3 subtype).

Targets

Muscarinic acetylcholine receptors (M1, M3, M5) · Muscarinic acetylcholine receptor (M1) · Muscarinic acetylcholine receptors (M3 subtype) · Muscarinic acetylcholine receptors (M1-M5, primarily M3 in ocular tissue) · Muscarinic acetylcholine receptors (M1-M5) · Acetylcholinesterase (neostigmine); Muscarinic acetylcholine receptors (glycopyrrolate) · Muscarinic acetylcholine receptors · Acetylcholinesterase (neostigmine); muscarinic acetylcholine receptors (glycopyrrolate) · Acetylcholinesterase; muscarinic acetylcholine receptors · Muscarinic acetylcholine receptor (M3)

Marketed (31)

• scopolamine transdermal · Stony Brook University · Gastroenterology / Antiemetics
  Scopolamine blocks muscarinic acetylcholine receptors in the central nervous system to prevent nausea and vomiting.
• Transdermal Scopolamine · Repurposed Therapeutics, Inc. · Gastroenterology / Neurology
  Transdermal scopolamine blocks muscarinic acetylcholine receptors to reduce motion sickness and nausea by decreasing vestibular sensitivity and gastric motility.
• Trospium Cl · Toronto Rehabilitation Institute · Urology
  Trospium chloride is an anticholinergic agent that blocks muscarinic receptors in the bladder smooth muscle, reducing involuntary contractions and urinary urgency.
• Atropine 1% · Massachusetts Eye and Ear Infirmary · Ophthalmology
  Atropine blocks muscarinic acetylcholine receptors to inhibit parasympathetic activity, causing pupil dilation and cycloplegia when applied topically to the eye.
• Atropine 0.04% · Beijing Tongren Hospital · Ophthalmology
  Atropine blocks muscarinic acetylcholine receptors to inhibit parasympathetic nervous system activity.
• Neostigmine and Glycopyrrolate · James J. Peters Veterans Affairs Medical Center · Neurology
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while glycopyrrolate blocks muscarinic receptors to counteract cholinergic side effects.
• Atropine 0.01% · University Hospital, Strasbourg, France · Ophthalmology
  Atropine blocks muscarinic acetylcholine receptors, preventing parasympathetic nervous system signaling.
• Intravenous scopolamine hydrobromide · University of Iowa · Anesthesia and Perioperative Medicine
  Scopolamine is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce secretions and motion-induced nausea.
• Neostigmine w/ Glycopyrrolate · University of Texas Southwestern Medical Center · Neurology
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while glycopyrrolate blocks muscarinic receptors to counteract cholinergic side effects.
• Neostigmine with glycopyrrolate · The Cleveland Clinic · Neurology
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while glycopyrrolate blocks muscarinic receptors to counteract cholinergic side effects.
• Bencycloquidium Bromide Nasal Spray · Yingu Pharmaceutical Co., Ltd · Respiratory / Allergy
  Bencycloquidium bromide is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce nasal secretions and congestion.
• ACs · GlaxoSmithKline · Multiple (Respiratory, Gastrointestinal, Ophthalmology, Neurology)
  ACs are anticholinergic agents that block acetylcholine receptors to reduce parasympathetic nervous system activity.
• Oxybutynin chloride, extended-release · US Department of Veterans Affairs · Urology
  Oxybutynin chloride is an anticholinergic agent that blocks muscarinic acetylcholine receptors in the bladder smooth muscle, reducing involuntary contractions and increasing bladder capacity.
• Atropine Sulfate 1% Oph Soln · State University of New York College of Optometry · Ophthalmology
  Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation.
• Atropine Sulfate 0.04% Eye Drop · Shanghai Eye Disease Prevention and Treatment Center · Ophthalmology
  Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation.
• Neostigmine + Atropine · China Medical University Hospital · Neurology
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while atropine blocks muscarinic receptors to counteract excessive parasympathomimetic effects.
• Neostigmine+Glycopyrronium · Pusan National University Yangsan Hospital · Neurology
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while glycopyrronium blocks muscarinic receptors to counteract cholinergic side effects.
• scopolamine patch · Rutgers, The State University of New Jersey · Gastroenterology / Neurology
  Scopolamine blocks muscarinic acetylcholine receptors in the central nervous system to prevent nausea and vomiting.
• Slow dose preemptive Atropine · Abant Izzet Baysal University · Toxicology / Emergency Medicine
  Slow dose preemptive atropine blocks muscarinic acetylcholine receptors to prevent cholinergic toxicity and organophosphate poisoning effects.
• Oxybutinin Extended-Release · Janssen-Cilag Ltd.,Thailand · Urology
  Oxybutynin is an anticholinergic agent that blocks muscarinic acetylcholine receptors in the bladder smooth muscle, reducing involuntary contractions and increasing bladder capacity.
• Transderm Scop® · University of Iowa · Gastroenterology / Anesthesia
  Scopolamine blocks muscarinic acetylcholine receptors to prevent nausea and vomiting by reducing vestibular and chemoreceptor trigger zone activity.
• Solifenacin plus Tamsulosin · Soonchunhyang University Hospital · Urology
  Solifenacin blocks muscarinic receptors in the bladder to reduce overactive bladder symptoms, while tamsulosin relaxes smooth muscle in the prostate and urethra to improve urinary flow.
• Oxybutynin ER · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. · Urology / Neurology
  Oxybutynin is an anticholinergic agent that blocks muscarinic acetylcholine receptors in the bladder smooth muscle, reducing involuntary contractions and increasing bladder capacity.
• Atropine sulfate and epinephrine · Dar El Oyoun Hospital · Emergency Medicine / Toxicology
  Atropine blocks muscarinic acetylcholine receptors to reduce parasympathetic effects, while epinephrine stimulates adrenergic receptors to increase heart rate and blood pressure.
• Active B&O suppository of belladonna · Edgar LeClaire, MD · Gastroenterology
  Belladonna alkaloids block muscarinic acetylcholine receptors to reduce smooth muscle contractions and secretions in the gastrointestinal and urinary tracts.
• neostigmine/glycopyrolate · Henry Ford Health System · Neurology / Anesthesia
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while glycopyrolate blocks muscarinic receptors to counteract parasympathomimetic side effects.
• eye drops (Tropicamid) · Medical University of Graz · Ophthalmology
  Tropicamide is an anticholinergic agent that blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation.
• Topical cyclopentolate and phenylephrine · Dar El Oyoun Hospital · Ophthalmology
  Cyclopentolate blocks muscarinic acetylcholine receptors to cause mydriasis and cycloplegia, while phenylephrine stimulates alpha-1 adrenergic receptors to enhance mydriasis.
• Postop orphenadrine IV · AdventHealth · Pain Management / Anesthesia
  Orphenadrine is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce muscle spasms and provide analgesic effects.
• Solifenacin with vaginal estrogen cream · Mackay Memorial Hospital · Urology / Gynecology
  Solifenacin blocks muscarinic receptors to reduce overactive bladder contractions, while vaginal estrogen cream restores local estrogen levels to improve vaginal atrophy and urogenital symptoms.
• Neostigmine + Glycopyrrolate · Merck Sharp & Dohme LLC · Neuromuscular
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while glycopyrrolate blocks muscarinic receptors to prevent cholinergic side effects.

Phase 3 pipeline (14)

• Atropine sulfate eye drops 0.02% · Oupushifang Pharmaceutical Technology Co., Ltd. · Ophthalmology
  Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation, slowing myopia progression in children.
• glycopyrronium Topical Wipes · Journey Medical Corporation · Dermatology
  Glycopyrronium is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce sweat gland secretion.
• neostigmine and glycopyrrolate or atropine · Merck Sharp & Dohme LLC · Neuromuscular disorders
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while glycopyrrolate or atropine blocks muscarinic receptors to prevent cholinergic side effects.
• OROS® oxybutynin or Ditropan® · Alza Corporation, DE, USA · Urology / Neurology
  Oxybutynin is an anticholinergic agent that blocks muscarinic acetylcholine receptors in the bladder smooth muscle, reducing involuntary contractions and increasing bladder capacity.
• Atropine Ophthalmic 0.5% · Erasmus Medical Center · Ophthalmology
  Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation.
• OROS® oxybutynin · Alza Corporation, DE, USA · Urology / Gastroenterology
  OROS oxybutynin is an anticholinergic agent that blocks muscarinic receptors in the bladder smooth muscle, reducing involuntary contractions and increasing bladder capacity.
• scopolamine HBr · Repurposed Therapeutics, Inc. · Neurology / Gastroenterology
  Scopolamine HBr is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce secretions and motion-induced nausea.
• Buscopan® Composto association · EMS · Gastroenterology
  Buscopan Composto combines hyoscine butylbromide (an anticholinergic agent) with paracetamol to relieve abdominal pain and cramping while reducing fever.
• Atropine Ophthalmic 0.05% · Erasmus Medical Center · Ophthalmology
  Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation.
• Atropine Sulfate 01 · LitePharmTech Co., Ltd. · Emergency Medicine, Anesthesia, Ophthalmology, Toxicology
  Atropine sulfate is an anticholinergic agent that blocks muscarinic acetylcholine receptors to inhibit parasympathetic nervous system activity.
• Oxybutynin Transdermal Patch · University of California, Davis · Urology / Neurology
  Oxybutynin is an anticholinergic agent that blocks muscarinic acetylcholine receptors in the bladder smooth muscle, reducing involuntary contractions and increasing bladder capacity.
• Combination of Neostigmine and Glycopyrrolate · James J. Peters Veterans Affairs Medical Center · Neuromuscular / Anesthesia
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while glycopyrrolate blocks muscarinic receptors to counteract parasympathomimetic side effects.
• Atropine Sulfate 02 · LitePharmTech Co., Ltd. · Emergency Medicine, Ophthalmology, Cardiology
  Atropine sulfate is an anticholinergic agent that blocks muscarinic acetylcholine receptors to inhibit parasympathetic nervous system activity.
• Atropine Sulfate 03 · LitePharmTech Co., Ltd. · Emergency Medicine, Ophthalmology, Cardiology
  Atropine sulfate is an anticholinergic agent that blocks muscarinic acetylcholine receptors to inhibit parasympathetic nervous system activity.

Phase 2 pipeline (1)

• Iontophoresis with acetylcholine delivery · Assistance Publique - Hôpitaux de Paris · Neurology
  Acetylcholine delivery via iontophoresis stimulates nicotinic acetylcholine receptors.

Patent intelligence

• cholinergic agent patent landscape — aggregated cliff calendar, attackable patents, originator estates