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Active B&O suppository of belladonna
Active B&O suppository of belladonna is a Anticholinergic agent Small molecule drug developed by Edgar LeClaire, MD. It is currently FDA-approved for Abdominal cramping and spasms, Irritable bowel syndrome symptoms.
Belladonna alkaloids block muscarinic acetylcholine receptors to reduce smooth muscle contractions and secretions in the gastrointestinal and urinary tracts.
Belladonna alkaloids block muscarinic acetylcholine receptors to reduce smooth muscle contractions and secretions in the gastrointestinal and urinary tracts. Used for Abdominal cramping and spasms, Irritable bowel syndrome symptoms.
At a glance
| Generic name | Active B&O suppository of belladonna |
|---|---|
| Sponsor | Edgar LeClaire, MD |
| Drug class | Anticholinergic agent |
| Target | Muscarinic acetylcholine receptors (M1-M5) |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Belladonna contains tropane alkaloids (primarily scopolamine and hyoscyamine) that act as anticholinergic agents. When administered rectally via suppository, these compounds inhibit parasympathetic nervous system signaling by antagonizing muscarinic receptors on smooth muscle and glandular tissues. This results in decreased intestinal motility, reduced secretions, and relief of spasms in the lower gastrointestinal tract.
Approved indications
- Abdominal cramping and spasms
- Irritable bowel syndrome symptoms
Common side effects
- Dry mouth
- Constipation
- Urinary retention
- Dizziness
- Blurred vision
Key clinical trials
- The Use of Belladonna and Opium Suppository in the Treatment of Postoperative Stent Pain (PHASE4)
- Reduction of Bladder Injection Pain With Belladonna Opiate Suppository (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Active B&O suppository of belladonna CI brief — competitive landscape report
- Active B&O suppository of belladonna updates RSS · CI watch RSS
- Edgar LeClaire, MD portfolio CI
Frequently asked questions about Active B&O suppository of belladonna
What is Active B&O suppository of belladonna?
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Related
- Drug class: All Anticholinergic agent drugs
- Target: All drugs targeting Muscarinic acetylcholine receptors (M1-M5)
- Manufacturer: Edgar LeClaire, MD — full pipeline
- Therapeutic area: All drugs in Gastroenterology
- Indication: Drugs for Abdominal cramping and spasms
- Indication: Drugs for Irritable bowel syndrome symptoms
- Compare: Active B&O suppository of belladonna vs similar drugs
- Pricing: Active B&O suppository of belladonna cost, discount & access