{"id":"active-b-o-suppository-of-belladonna","safety":{"commonSideEffects":[{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Blurred vision"}]},"_chembl":{"chemblId":"CHEMBL2108906","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Belladonna contains tropane alkaloids (primarily scopolamine and hyoscyamine) that act as anticholinergic agents. When administered rectally via suppository, these compounds inhibit parasympathetic nervous system signaling by antagonizing muscarinic receptors on smooth muscle and glandular tissues. This results in decreased intestinal motility, reduced secretions, and relief of spasms in the lower gastrointestinal tract.","oneSentence":"Belladonna alkaloids block muscarinic acetylcholine receptors to reduce smooth muscle contractions and secretions in the gastrointestinal and urinary tracts.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:17:31.187Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Abdominal cramping and spasms"},{"name":"Irritable bowel syndrome symptoms"}]},"trialDetails":[{"nctId":"NCT03332056","phase":"PHASE4","title":"The Use of Belladonna and Opium Suppository in the Treatment of Postoperative Stent Pain","status":"COMPLETED","sponsor":"University of Washington","startDate":"2013-08","conditions":"Nephrolithiasis","enrollment":71},{"nctId":"NCT02600715","phase":"PHASE4","title":"Reduction of Bladder Injection Pain With Belladonna Opiate Suppository","status":"COMPLETED","sponsor":"Edgar LeClaire, MD","startDate":"2015-11","conditions":"Overactive Bladder, Urinary Urge Incontinence, Urinary Bladder, Neurogenic","enrollment":26}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Active B&O suppository of belladonna","genericName":"Active B&O suppository of belladonna","companyName":"Edgar LeClaire, MD","companyId":"edgar-leclaire-md","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Belladonna alkaloids block muscarinic acetylcholine receptors to reduce smooth muscle contractions and secretions in the gastrointestinal and urinary tracts. Used for Abdominal cramping and spasms, Irritable bowel syndrome symptoms.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}