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Atropine sulfate and epinephrine
Atropine sulfate and epinephrine is a Anticholinergic agent and sympathomimetic amine combination Small molecule drug developed by Dar El Oyoun Hospital. It is currently FDA-approved for Organophosphate or carbamate poisoning, Anaphylaxis, Severe bradycardia with hypotension. Also known as: Atropine (Misr.co), Epinephrine (Misr.co).
Atropine blocks muscarinic acetylcholine receptors to reduce parasympathetic effects, while epinephrine stimulates adrenergic receptors to increase heart rate and blood pressure.
Atropine blocks muscarinic acetylcholine receptors to reduce parasympathetic effects, while epinephrine stimulates adrenergic receptors to increase heart rate and blood pressure. Used for Organophosphate or carbamate poisoning, Anaphylaxis, Severe bradycardia with hypotension.
At a glance
| Generic name | Atropine sulfate and epinephrine |
|---|---|
| Also known as | Atropine (Misr.co), Epinephrine (Misr.co) |
| Sponsor | Dar El Oyoun Hospital |
| Drug class | Anticholinergic agent and sympathomimetic amine combination |
| Target | Muscarinic acetylcholine receptors (atropine); alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors (epinephrine) |
| Modality | Small molecule |
| Therapeutic area | Emergency Medicine / Toxicology |
| Phase | FDA-approved |
Mechanism of action
Atropine sulfate is an anticholinergic agent that antagonizes muscarinic receptors, reducing salivation, bronchial secretions, and vagal effects on the heart. Epinephrine is a sympathomimetic amine that activates alpha and beta adrenergic receptors, increasing cardiac output, blood pressure, and bronchial dilation. This combination is used in emergency settings to counteract severe parasympathomimetic poisoning or anaphylaxis.
Approved indications
- Organophosphate or carbamate poisoning
- Anaphylaxis
- Severe bradycardia with hypotension
Common side effects
- Tachycardia
- Hypertension
- Tremor
- Anxiety
- Dry mouth
- Mydriasis (dilated pupils)
- Arrhythmias
Key clinical trials
- Cerebral Oxygen Saturation Monitoring In Cardiac Surgery (COSMICS) (NA)
- Indenoisoquinoline LMP744 in Adults With Relapsed Solid Tumors and Lymphomas (PHASE1)
- Decision Support for Intraoperative Low Blood Pressure (NA)
- Phase I, Placebo-Controlled, Blinded Pilot Study of Ipratropium in Children Admitted to the ICU With Status Asthmaticus (PHASE1)
- Subconjunctival Atropine and Intracameral Epinephrine for Pupil Dilation in Phacoemulsification (PHASE4)
- Role of Low Dose Epinephrine Boluses In Acute Hypotension (NA)
- In-hospital Cardiac Arrest - Dynamics and State Transitions
- Effectiveness of Caudal Epidural Block on Intraoperative Blood Loss During Hypospadias Repair (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Atropine sulfate and epinephrine CI brief — competitive landscape report
- Atropine sulfate and epinephrine updates RSS · CI watch RSS
- Dar El Oyoun Hospital portfolio CI
Frequently asked questions about Atropine sulfate and epinephrine
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Related
- Drug class: All Anticholinergic agent and sympathomimetic amine combination drugs
- Target: All drugs targeting Muscarinic acetylcholine receptors (atropine); alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors (epinephrine)
- Manufacturer: Dar El Oyoun Hospital — full pipeline
- Therapeutic area: All drugs in Emergency Medicine / Toxicology
- Indication: Drugs for Organophosphate or carbamate poisoning
- Indication: Drugs for Anaphylaxis
- Indication: Drugs for Severe bradycardia with hypotension
- Also known as: Atropine (Misr.co), Epinephrine (Misr.co)
- Compare: Atropine sulfate and epinephrine vs similar drugs
- Pricing: Atropine sulfate and epinephrine cost, discount & access