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Topical cyclopentolate and phenylephrine
Topical cyclopentolate and phenylephrine is a Anticholinergic agent + alpha-1 adrenergic agonist Small molecule drug developed by Dar El Oyoun Hospital. It is currently FDA-approved for Mydriasis and cycloplegia for ophthalmic examination and refraction, Mydriasis for ophthalmic diagnostic procedures. Also known as: Cyclophrine eye drops.
Cyclopentolate blocks muscarinic acetylcholine receptors to cause mydriasis and cycloplegia, while phenylephrine stimulates alpha-1 adrenergic receptors to enhance mydriasis.
Topical cyclopentolate and phenylephrine are small molecule medications used to treat conditions such as cataract and corneal endothelial cell loss, and to induce mydriasis. They are administered topically and have been studied in clinical trials for their efficacy and safety in these applications.
At a glance
| Generic name | Topical cyclopentolate and phenylephrine |
|---|---|
| Also known as | Cyclophrine eye drops |
| Sponsor | Dar El Oyoun Hospital |
| Drug class | Anticholinergic agent + alpha-1 adrenergic agonist |
| Target | Muscarinic acetylcholine receptor (cyclopentolate); alpha-1 adrenergic receptor (phenylephrine) |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | FDA-approved |
Mechanism of action
Cyclopentolate is an anticholinergic agent that paralyzes the ciliary muscle and dilates the pupil by blocking parasympathetic signaling. Phenylephrine is an alpha-1 adrenergic agonist that further dilates the pupil through sympathomimetic action. Together, this combination produces rapid and pronounced mydriasis and cycloplegia for diagnostic and therapeutic ophthalmic procedures.
Approved indications
- Mydriasis and cycloplegia for ophthalmic examination and refraction
- Mydriasis for ophthalmic diagnostic procedures
Common side effects
- Transient stinging or irritation
- Blurred vision
- Photophobia
- Increased intraocular pressure
- Systemic anticholinergic effects (rare with topical use)
Key clinical trials
- Effect of Intracameral Injection of Mydriatic Plus Anaesthetic Combination on Corneal Endothelial Count in Phaco (PHASE3)
- Optimal Method for Mydriasis in Cataract Surgery (NA)
- Subconjunctival Atropine and Intracameral Epinephrine for Pupil Dilation in Phacoemulsification (PHASE4)
- Lidocaine Usage for Pupil Dilatation (Mydriasis) (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Topical cyclopentolate and phenylephrine CI brief — competitive landscape report
- Topical cyclopentolate and phenylephrine updates RSS · CI watch RSS
- Dar El Oyoun Hospital portfolio CI
Frequently asked questions about Topical cyclopentolate and phenylephrine
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Related
- Drug class: All Anticholinergic agent + alpha-1 adrenergic agonist drugs
- Target: All drugs targeting Muscarinic acetylcholine receptor (cyclopentolate); alpha-1 adrenergic receptor (phenylephrine)
- Manufacturer: Dar El Oyoun Hospital — full pipeline
- Therapeutic area: All drugs in Ophthalmology
- Indication: Drugs for Mydriasis and cycloplegia for ophthalmic examination and refraction
- Indication: Drugs for Mydriasis for ophthalmic diagnostic procedures
- Also known as: Cyclophrine eye drops
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing