Prostaglandin analog + carbonic anhydrase inhibitor + beta-blocker combination
This page covers all Prostaglandin analog + carbonic anhydrase inhibitor + beta-blocker combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Prostaglandin F receptor (FP receptor); carbonic anhydrase II; beta-adrenergic receptors, Beta-2 adrenergic receptor (timolol); carbonic anhydrase II (dorzolamide), Carbonic anhydrase II; Beta-adrenergic receptors (β1 and β2).
Targets
Prostaglandin F receptor (FP receptor); carbonic anhydrase II; beta-adrenergic receptors · Beta-2 adrenergic receptor (timolol); carbonic anhydrase II (dorzolamide) · Carbonic anhydrase II; Beta-adrenergic receptors (β1 and β2) · Carbonic anhydrase II · Carbonic anhydrase 2 · Carbonic anhydrase (acetazolamide component); oxygen delivery and airway pressure modulation (supportive components) · Carbonic anhydrase · Na-K-2Cl cotransporter (furosemide); carbonic anhydrase (acetazolamide) · Carbonic anhydrase 1 · Carbonic anhydrase II, beta-2 adrenergic receptor, alpha-2A adrenergic receptor, prostaglandin F receptor
Marketed (25)
- Xalatan+Cosopt · University of Turin, Italy · Ophthalmology
This combination reduces intraocular pressure by combining a prostaglandin analog (latanoprost) that increases uveoscleral outflow with a carbonic anhydrase inhibitor and beta-blocker (dorzolamide/timolol) that decrease aqueous humor production. - timolol maleate and dorzolamide hydrochloride · University of Florida · Ophthalmology
This combination reduces intraocular pressure by decreasing aqueous humor production (timolol via beta-adrenergic blockade) and increasing aqueous humor outflow (dorzolamide via carbonic anhydrase inhibition). - treatment with dorzolamide/timolol · Aristotle University Of Thessaloniki · Ophthalmology
Dorzolamide/timolol is a fixed-dose combination that reduces intraocular pressure by inhibiting carbonic anhydrase (dorzolamide) and blocking beta-adrenergic receptors (timolol). - ACETAZOLAMIDE oral capsule · University of Zurich · Ophthalmology, Neurology, Urology
Acetazolamide inhibits carbonic anhydrase, reducing bicarbonate reabsorption in the kidney and promoting diuresis and alkalinization of urine. - Trusopt · Merck & Co. · Cardiovascular
Trusopt works by inhibiting the enzyme carbonic anhydrase 2, which is involved in the production of aqueous humor in the eye. - Acetazolamide + supplemental oxygen + PAP therapy · VA Office of Research and Development · Pulmonary/Respiratory, High-Altitude Medicine
This combination therapy reduces periodic breathing and improves oxygenation in high-altitude pulmonary edema (HAPE) and related conditions by suppressing respiratory alkalosis, providing supplemental oxygen, and applying positive airway pressure. - Intravenous acetazolamide · National University Hospital, Singapore · Ophthalmology, Neurology, Nephrology
Acetazolamide inhibits carbonic anhydrase, reducing bicarbonate reabsorption in the kidney and promoting diuresis and alkalinization of urine. - Diamox · Teva · Immunology
- Placebo-acetazolamide · Shahid Beheshti University of Medical Sciences · Ophthalmology
Acetazolamide inhibits carbonic anhydrase to reduce aqueous humor production and intraocular pressure, while the placebo component serves as a control in clinical evaluation. - IV Furosemide and IV Acetazolamide · Rambam Health Care Campus · Cardiovascular / Nephrology
This combination uses furosemide (a loop diuretic) to increase urine output and acetazolamide (a carbonic anhydrase inhibitor) to promote bicarbonate and electrolyte excretion, together enhancing diuresis and reducing fluid overload. - Keveyis · Ophthalmology
Keveyis works by inhibiting the enzyme carbonic anhydrase, which is involved in the production of aqueous humor in the eye. - Dorzolamide-timolol-brimonidine and latanoprost · Laboratorios Sophia S.A de C.V. · Ophthalmology
This fixed-dose combination reduces intraocular pressure through four complementary mechanisms: carbonic anhydrase inhibition, beta-adrenergic blockade, alpha-2 adrenergic agonism, and prostaglandin F analog activity. - Dorzolamide-timolol and latanoprost · Laboratorios Sophia S.A de C.V. · Ophthalmology
This combination reduces intraocular pressure through three mechanisms: dorzolamide inhibits carbonic anhydrase to decrease aqueous humor production, timolol blocks beta-adrenergic receptors to reduce aqueous humor secretion, and latanoprost increases uveoscleral outflow of aqueous humor. - Cosopt PF 2%-0.5% Ophthalmic Solution · Prairie Eye Center · Ophthalmology
Cosopt PF combines a topical carbonic anhydrase inhibitor (dorzolamide) and a beta-blocker (timolol) to reduce intraocular pressure through decreased aqueous humor production. - Brinzolamide/Brimonidine FC · University Hospital of Patras · Ophthalmology
This fixed combination reduces intraocular pressure by inhibiting carbonic anhydrase (brinzolamide) and activating alpha-2 adrenergic receptors (brimonidine). - Low Dose Acetazolamide · University of Utah · Ophthalmology; Pulmonology
Acetazolamide inhibits carbonic anhydrase to reduce bicarbonate reabsorption in the kidney, promoting diuresis and alkalinizing urine while lowering intraocular pressure. - Methazolamide Pill · University of Waterloo · Ophthalmology
Methazolamide inhibits carbonic anhydrase, reducing aqueous humor production in the eye to lower intraocular pressure. - Azopt · Novartis · Cardiovascular
Brinzolamide reduces intraocular pressure by inhibiting carbonic anhydrase II, decreasing aqueous humor secretion. - dorzolamide/timolol · CT Glaucoma Associates · Ophthalmology
Dorzolamide inhibits carbonic anhydrase to reduce aqueous humor production, while timolol blocks beta-adrenergic receptors to further decrease intraocular pressure. - tafluprost and dorzolamide/timolol · Aristotle University Of Thessaloniki · Ophthalmology
This combination reduces intraocular pressure by increasing uveoscleral outflow via prostaglandin F analogue activity and decreasing aqueous humor production via carbonic anhydrase inhibition and beta-blockade. - Drug: dorzolamide/timolol · Aristotle University Of Thessaloniki · Ophthalmology
Dorzolamide inhibits carbonic anhydrase to reduce aqueous humor production, while timolol blocks beta-adrenergic receptors to further decrease intraocular pressure. - Dorzolamide 2% drops · University Health Network, Toronto · Cardiovascular
- dorzolamide/timolol maleate fixed combination · Pharmaceutical Research Network · Ophthalmology
Dorzolamide inhibits carbonic anhydrase to reduce aqueous humor production, while timolol blocks beta-adrenergic receptors to further decrease intraocular pressure. - Latanoprost, Dorzolamide · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · Ophthalmology
This combination reduces intraocular pressure by increasing uveoscleral outflow of aqueous humor (latanoprost) and decreasing aqueous humor production (dorzolamide). - Simbrinza 0.2%-1% Ophthalmic Suspension · Prairie Eye Center · Ophthalmology
Simbrinza combines a beta-adrenergic antagonist and a carbonic anhydrase inhibitor to reduce intraocular pressure by decreasing aqueous humor production.
Phase 3 pipeline (16)
- Dichlorphenamide (open-label) · University of Rochester · Ophthalmology
Dichlorphenamide inhibits carbonic anhydrase to reduce aqueous humor production and intraocular pressure. - Comparator: dorzolamide hydrochloride · Merck Sharp & Dohme LLC · Ophthalmology
Dorzolamide hydrochloride inhibits carbonic anhydrase II in the eye, reducing aqueous humor production and lowering intraocular pressure. - Brinzolamide/brimonidine ophthalmic suspension · Padagis LLC · Ophthalmology
Brinzolamide reduces aqueous humor production via carbonic anhydrase inhibition, while brimonidine decreases aqueous humor production and increases uveoscleral outflow via alpha-2 adrenergic receptor agonism, together lowering intraocular pressure. - Topical ocular hypotensive eye drops. · Washington University School of Medicine · Ophthalmology
Reduces intraocular pressure by decreasing aqueous humor production. - Acetazolamide-based medical therapy · Beijing Tiantan Hospital · Ophthalmology, Neurology
Acetazolamide inhibits carbonic anhydrase to reduce aqueous humor production and cerebrospinal fluid formation, thereby lowering intraocular and intracranial pressure. - Acetazolamide Levamisole · The First Affiliated Hospital of Zhengzhou University · Ophthalmology / Glaucoma
This combination drug pairs acetazolamide (a carbonic anhydrase inhibitor) with levamisole (an immunomodulator) to reduce intraocular pressure while enhancing immune function. - Test-Brinzolamide 1% Ophthalmic suspension · Actavis Inc. · Ophthalmology
Test-Brinzolamide 1% Ophthalmic suspension works by reducing intraocular pressure by increasing the outflow of aqueous humor. - Azopt 1% · Bausch & Lomb Incorporated · Ophthalmology
Azopt is a topical carbonic anhydrase inhibitor that reduces intraocular pressure by decreasing aqueous humor production in the eye. - DOR/ISL · Merck Sharp & Dohme LLC · Ophthalmology
DOR/ISL is a combination of dorzolamide (a carbonic anhydrase inhibitor) and islatamide (a prostaglandin analog) that reduces intraocular pressure through dual mechanisms. - Dorzolamide 2 % eye drops solution · Alfred E. Tiefenbacher (GmbH & Co. KG) · Ophthalmology
Dorzolamide inhibits carbonic anhydrase II in the eye to reduce aqueous humor production and lower intraocular pressure. - Reference-Brinzolamide 1% Ophthalmic suspension · Actavis Inc. · Ophthalmology
Reference-Brinzolamide 1% Ophthalmic suspension works by reducing intraocular pressure by increasing the outflow of aqueous humor. - Travoprost/ Timolol/ Azopt/ Brimonidine · Singapore Eye Research Institute · Ophthalmology
Travoprost is a prostaglandin F2α analogue that lowers intraocular pressure by increasing uveoscleral outflow, while Timolol is a non-selective beta-adrenergic receptor blocker that reduces intraocular pressure by decreasing aqueous humor production. Azopt is a carbonic anhydrase inhibitor that decreases intraocular pressure by reducing aqueous humor production. Brimonidine is an α2-adrenergic receptor agonist that decreases intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. - Azopt 1% Ophthalmic Suspension · Padagis LLC · Ophthalmology
Azopt is a carbonic anhydrase inhibitor that reduces aqueous humor production in the eye to lower intraocular pressure. - brinzolamide 1% ophthalmic suspension · Bausch & Lomb Incorporated · Ophthalmology
Brinzolamide is a carbonic anhydrase inhibitor that reduces aqueous humor production in the eye. - Brinzolamide ophthalmic suspension · Sun Pharmaceutical Industries Limited · Ophthalmology
Brinzolamide is a carbonic anhydrase inhibitor that reduces aqueous humor production in the eye, thereby lowering intraocular pressure. - Travatan/ Timolol/Azopt · Singapore National Eye Centre · Ophthalmology
Travatan/Timolol/Azopt is a combination of a prostaglandin analog and a beta-blocker used to lower intraocular pressure in glaucoma patients.
Phase 1 pipeline (1)
- Acetazolamide first, then Furosemide · Rabin Medical Center · Ophthalmology
Acetazolamide inhibits carbonic anhydrase, reducing the formation of bicarbonate ions and increasing urinary excretion of sodium, potassium, and water.
Patent intelligence
- carbonic anhydrase inhibitor patent landscape — aggregated cliff calendar, attackable patents, originator estates