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Methazolamide Pill
Methazolamide inhibits carbonic anhydrase, reducing aqueous humor production in the eye to lower intraocular pressure.
Methazolamide inhibits carbonic anhydrase, reducing aqueous humor production in the eye to lower intraocular pressure. Used for Glaucoma, Ocular hypertension, Angle-closure glaucoma (acute attacks).
At a glance
| Generic name | Methazolamide Pill |
|---|---|
| Sponsor | University of Waterloo |
| Drug class | Carbonic anhydrase inhibitor |
| Target | Carbonic anhydrase |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | FDA-approved |
Mechanism of action
Methazolamide is a carbonic anhydrase inhibitor that decreases the production of aqueous humor by inhibiting the enzyme carbonic anhydrase in the ciliary body of the eye. By reducing aqueous humor formation, the drug lowers intraocular pressure, which helps prevent optic nerve damage and vision loss in glaucoma and ocular hypertension. It is a systemic (oral) medication with a longer duration of action compared to topical carbonic anhydrase inhibitors.
Approved indications
- Glaucoma
- Ocular hypertension
- Angle-closure glaucoma (acute attacks)
Common side effects
- Paresthesia (tingling in fingers, toes, lips)
- Altered taste (especially carbonated beverages)
- Fatigue
- Headache
- Nausea
- Hypokalemia (low potassium)
Key clinical trials
- Effect of Acetazolamide and Methazolamide on Hypoxic Exercise Performance (PHASE4)
- Three New Ideas to Protect Special Forces From the Stress of High Altitude (PHASE4)
- Muscle Fatigue and Carbonic Anhydrase Inhibitors (PHASE4)
- AZ, MZ, and the Pulmonary System Response to Hypoxia (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Methazolamide Pill CI brief — competitive landscape report
- Methazolamide Pill updates RSS · CI watch RSS
- University of Waterloo portfolio CI