{"id":"methazolamide-pill","safety":{"commonSideEffects":[{"rate":null,"effect":"Paresthesia (tingling in fingers, toes, lips)"},{"rate":null,"effect":"Altered taste (especially carbonated beverages)"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Hypokalemia (low potassium)"}]},"_chembl":{"chemblId":"CHEMBL19","moleculeType":"Small molecule","molecularWeight":"236.28"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methazolamide is a carbonic anhydrase inhibitor that decreases the production of aqueous humor by inhibiting the enzyme carbonic anhydrase in the ciliary body of the eye. By reducing aqueous humor formation, the drug lowers intraocular pressure, which helps prevent optic nerve damage and vision loss in glaucoma and ocular hypertension. It is a systemic (oral) medication with a longer duration of action compared to topical carbonic anhydrase inhibitors.","oneSentence":"Methazolamide inhibits carbonic anhydrase, reducing aqueous humor production in the eye to lower intraocular pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:39.845Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Glaucoma"},{"name":"Ocular hypertension"},{"name":"Angle-closure glaucoma (acute attacks)"}]},"trialDetails":[{"nctId":"NCT05575180","phase":"PHASE4","title":"Effect of Acetazolamide and Methazolamide on Hypoxic Exercise Performance","status":"COMPLETED","sponsor":"University of Waterloo","startDate":"2023-08-11","conditions":"High Altitude Effects","enrollment":15},{"nctId":"NCT02463357","phase":"PHASE4","title":"Three New Ideas to Protect Special Forces From the Stress of High Altitude","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2015-08","conditions":"Mountain Sickness","enrollment":148},{"nctId":"NCT02758470","phase":"PHASE4","title":"Muscle Fatigue and Carbonic Anhydrase Inhibitors","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2016-11","conditions":"Hypoxia","enrollment":13},{"nctId":"NCT02760121","phase":"PHASE4","title":"AZ, MZ, and the Pulmonary System Response to Hypoxia","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2016-05","conditions":"Altitude Sickness, Hypertension, Pulmonary","enrollment":14}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Methazolamide Pill","genericName":"Methazolamide Pill","companyName":"University of Waterloo","companyId":"university-of-waterloo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methazolamide inhibits carbonic anhydrase, reducing aqueous humor production in the eye to lower intraocular pressure. Used for Glaucoma, Ocular hypertension, Angle-closure glaucoma (acute attacks).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}