Last reviewed · How we verify
Brinzolamide ophthalmic suspension
Brinzolamide ophthalmic suspension is a Carbonic anhydrase inhibitor Small molecule drug developed by Sun Pharmaceutical Industries Limited. It is currently in Phase 3 development for Elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Brinzolamide is a carbonic anhydrase inhibitor that reduces aqueous humor production in the eye, thereby lowering intraocular pressure.
Brinzolamide is a carbonic anhydrase inhibitor that reduces aqueous humor production in the eye, thereby lowering intraocular pressure. Used for Elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
At a glance
| Generic name | Brinzolamide ophthalmic suspension |
|---|---|
| Sponsor | Sun Pharmaceutical Industries Limited |
| Drug class | Carbonic anhydrase inhibitor |
| Target | Carbonic anhydrase II |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | Phase 3 |
Mechanism of action
Brinzolamide inhibits carbonic anhydrase II in the ciliary body of the eye, which decreases the secretion of aqueous humor. By reducing aqueous humor production, the drug lowers intraocular pressure, which is the primary therapeutic goal in glaucoma and ocular hypertension management. The ophthalmic suspension formulation allows direct topical delivery to the eye.
Approved indications
- Elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma
Common side effects
- Blurred vision
- Ocular discomfort or irritation
- Taste perversion
- Headache
Key clinical trials
- Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost (PHASE4)
- To Compare the Efficacy and Safety of Perrigo's Product to an FDA Approved Product for the Treatment of Glaucoma or Ocular Hypertension in Both Eyes (PHASE3)
- A Therapeutic Equivalence Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension (PHASE3)
- Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt (PHASE3)
- Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt (PHASE1, PHASE2)
- To Compare the Safety and Efficacy of Perrigo's Product to an FDA Approved Product for the Treatment of Glaucoma or Ocular Hypertension in Both Eyes (PHASE3)
- Brinzolamide-brimonidine Fixed Combination for Preventing IOP Elevation After Intravitreal Anti-VEGF Injections (NA)
- Bioequivalence Study With Clinical Endpoint Comparing Brinzolamide 1% Ophthalmic Suspension to Azopt® 1% Ophthalmic Suspension In the Treatment of Chronic Open Angle Glaucoma or Ocular Hypertension in Both Eyes (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Brinzolamide ophthalmic suspension CI brief — competitive landscape report
- Brinzolamide ophthalmic suspension updates RSS · CI watch RSS
- Sun Pharmaceutical Industries Limited portfolio CI
Frequently asked questions about Brinzolamide ophthalmic suspension
What is Brinzolamide ophthalmic suspension?
How does Brinzolamide ophthalmic suspension work?
What is Brinzolamide ophthalmic suspension used for?
Who makes Brinzolamide ophthalmic suspension?
What drug class is Brinzolamide ophthalmic suspension in?
What development phase is Brinzolamide ophthalmic suspension in?
What are the side effects of Brinzolamide ophthalmic suspension?
What does Brinzolamide ophthalmic suspension target?
Related
- Drug class: All Carbonic anhydrase inhibitor drugs
- Target: All drugs targeting Carbonic anhydrase II
- Manufacturer: Sun Pharmaceutical Industries Limited — full pipeline
- Therapeutic area: All drugs in Ophthalmology
- Indication: Drugs for Elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma
- Compare: Brinzolamide ophthalmic suspension vs similar drugs
- Pricing: Brinzolamide ophthalmic suspension cost, discount & access