Carbonic anhydrase II — Drug Target

All drugs that target Carbonic anhydrase II — marketed and clinical-stage. Includes 2 drug classes acting on this target.

Drug classes

Carbonic anhydrase inhibitor · Carbonic Anhydrase Inhibitor [EPC]

Marketed (4)

• Dorzolamide 2% drops · University Health Network, Toronto · Carbonic anhydrase inhibitor · Cardiovascular
• Low Dose Acetazolamide · University of Utah · Carbonic anhydrase inhibitor · Ophthalmology; Pulmonology
  Acetazolamide inhibits carbonic anhydrase to reduce bicarbonate reabsorption in the kidney, promoting diuresis and alkalinizing urine while lowering intraocular pressure.
• Azopt · Novartis · Carbonic Anhydrase Inhibitor [EPC] · Cardiovascular
  Brinzolamide reduces intraocular pressure by inhibiting carbonic anhydrase II, decreasing aqueous humor secretion.
• ACETAZOLAMIDE oral capsule · University of Zurich · Carbonic anhydrase inhibitor · Ophthalmology, Neurology, Urology
  Acetazolamide inhibits carbonic anhydrase, reducing bicarbonate reabsorption in the kidney and promoting diuresis and alkalinization of urine.

Phase 3 pipeline (7)

• Test-Brinzolamide 1% Ophthalmic suspension · Actavis Inc. · Carbonic anhydrase inhibitor · Ophthalmology
  Test-Brinzolamide 1% Ophthalmic suspension works by reducing intraocular pressure by increasing the outflow of aqueous humor.
• Azopt 1% · Bausch & Lomb Incorporated · Carbonic anhydrase inhibitor · Ophthalmology
  Azopt is a topical carbonic anhydrase inhibitor that reduces intraocular pressure by decreasing aqueous humor production in the eye.
• Brinzolamide ophthalmic suspension · Sun Pharmaceutical Industries Limited · Carbonic anhydrase inhibitor · Ophthalmology
  Brinzolamide is a carbonic anhydrase inhibitor that reduces aqueous humor production in the eye, thereby lowering intraocular pressure.
• Dorzolamide 2 % eye drops solution · Alfred E. Tiefenbacher (GmbH & Co. KG) · Carbonic anhydrase inhibitor · Ophthalmology
  Dorzolamide inhibits carbonic anhydrase II in the eye to reduce aqueous humor production and lower intraocular pressure.
• Azopt 1% Ophthalmic Suspension · Padagis LLC · Carbonic anhydrase inhibitor · Ophthalmology
  Azopt is a carbonic anhydrase inhibitor that reduces aqueous humor production in the eye to lower intraocular pressure.
• Reference-Brinzolamide 1% Ophthalmic suspension · Actavis Inc. · Carbonic anhydrase inhibitor · Ophthalmology
  Reference-Brinzolamide 1% Ophthalmic suspension works by reducing intraocular pressure by increasing the outflow of aqueous humor.
• Comparator: dorzolamide hydrochloride · Merck Sharp & Dohme LLC · Carbonic anhydrase inhibitor · Ophthalmology
  Dorzolamide hydrochloride inhibits carbonic anhydrase II in the eye, reducing aqueous humor production and lowering intraocular pressure.