Last reviewed 2026-04-23 · How we verify

Travatan/ Timolol/Azopt

Travatan/Timolol/Azopt is a combination of a prostaglandin analog and a beta-blocker used to lower intraocular pressure in glaucoma patients.

Travatan/Timolol/Azopt is a combination of a prostaglandin analog and a beta-blocker used to lower intraocular pressure in glaucoma patients. Used for Glaucoma, Ocular hypertension.

At a glance

Mechanism of action

Travatan (travoprost) is a prostaglandin analog that increases the outflow of aqueous humor from the eye, while Timolol is a beta-blocker that reduces the production of aqueous humor. Azopt (brinzolamide) is a carbonic anhydrase inhibitor that also reduces aqueous humor production. This combination is used to treat glaucoma and ocular hypertension.

Approved indications

• Glaucoma, Ocular hypertension

Common side effects

• Headache
• Eye pain
• Blepharitis
• Dry mouth
• Dizziness

Key clinical trials

• Retinal Ganglion Cell Neuroprotection Under Prostaglandin Analogues
• Stop Retinal Ganglion Cell Dysfunction Study (PHASE3)
• 24-Hour Intraocular Pressure With Brinzolamide/Timolol Versus Brimonidine/Timolol (PHASE4)
• Choroidal Thickness and Its Correlations With Ocular Parameters in Primary Open-angle Glaucoma (PHASE4)
• Safety and Efficacy of SIMBRINZA® BID as an Adjunctive to DUOTRAV® (PHASE4)
• Effect of Prophylactic Aqueous Suppression on Hyperencapsulation of Ahmed Glaucoma Valves (PHASE4)
• Study of Brinzolamide and Timolol When Added to Travoprost in Primary Open-angle Glaucoma or Ocular Hypertension (PHASE4)
• IOP-Lowering Efficacy of Brinzolamide 1.0% Added to Travoprost 0.004%/Timolol 0.5% Fixed Combination as Adjunctive Therapy (PHASE4)

Primary sources

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