Carbonic anhydrase — Drug Target

All drugs that target Carbonic anhydrase — marketed and clinical-stage. Includes 2 drug classes acting on this target.

Drug classes

Carbonic Anhydrase Inhibitor [EPC] · Carbonic anhydrase inhibitor

Marketed (4)

• Diamox · Teva · Carbonic Anhydrase Inhibitor [EPC] · Immunology
• Intravenous acetazolamide · National University Hospital, Singapore · Carbonic anhydrase inhibitor · Ophthalmology, Neurology, Nephrology
  Acetazolamide inhibits carbonic anhydrase, reducing bicarbonate reabsorption in the kidney and promoting diuresis and alkalinization of urine.
• Methazolamide Pill · University of Waterloo · Carbonic anhydrase inhibitor · Ophthalmology
  Methazolamide inhibits carbonic anhydrase, reducing aqueous humor production in the eye to lower intraocular pressure.
• Placebo-acetazolamide · Shahid Beheshti University of Medical Sciences · Carbonic anhydrase inhibitor · Ophthalmology
  Acetazolamide inhibits carbonic anhydrase to reduce aqueous humor production and intraocular pressure, while the placebo component serves as a control in clinical evaluation.

Phase 3 pipeline (4)

• brinzolamide 1% ophthalmic suspension · Bausch & Lomb Incorporated · Carbonic anhydrase inhibitor · Ophthalmology
  Brinzolamide is a carbonic anhydrase inhibitor that reduces aqueous humor production in the eye.
• Acetazolamide-based medical therapy · Beijing Tiantan Hospital · Carbonic anhydrase inhibitor · Ophthalmology, Neurology
  Acetazolamide inhibits carbonic anhydrase to reduce aqueous humor production and cerebrospinal fluid formation, thereby lowering intraocular and intracranial pressure.
• Dichlorphenamide (open-label) · University of Rochester · Carbonic anhydrase inhibitor · Ophthalmology
  Dichlorphenamide inhibits carbonic anhydrase to reduce aqueous humor production and intraocular pressure.
• Topical ocular hypotensive eye drops. · Washington University School of Medicine · Carbonic anhydrase inhibitor · Ophthalmology
  Reduces intraocular pressure by decreasing aqueous humor production.

Phase 1 pipeline (1)

• Acetazolamide first, then Furosemide · Rabin Medical Center · Carbonic anhydrase inhibitor · Ophthalmology
  Acetazolamide inhibits carbonic anhydrase, reducing the formation of bicarbonate ions and increasing urinary excretion of sodium, potassium, and water.