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Travoprost/ Timolol/ Azopt/ Brimonidine
Travoprost/ Timolol/ Azopt/ Brimonidine is a Prostaglandin analogue, Beta blocker, Carbonic anhydrase inhibitor, Alpha-2 adrenergic agonist Small molecule drug developed by Singapore Eye Research Institute. It is currently in Phase 3 development for Glaucoma, Ocular hypertension.
Travoprost is a prostaglandin F2α analogue that lowers intraocular pressure by increasing uveoscleral outflow, while Timolol is a non-selective beta-adrenergic receptor blocker that reduces intraocular pressure by decreasing aqueous humor production. Azopt is a carbonic anhydrase inhibitor that decreases intraocular pressure by reducing aqueous humor production. Brimonidine is an α2-adrenergic receptor agonist that decreases intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow.
Travoprost is a prostaglandin F2α analogue that lowers intraocular pressure by increasing uveoscleral outflow, while Timolol is a non-selective beta-adrenergic receptor blocker that reduces intraocular pressure by decreasing aqueous humor production. Azopt is a carbonic anhydrase inhibitor that decreases intraocular pressure by reducing aqueous humor production. Brimonidine is an α2-adrenergic receptor agonist that decreases intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. Used for Glaucoma, Ocular hypertension.
At a glance
| Generic name | Travoprost/ Timolol/ Azopt/ Brimonidine |
|---|---|
| Sponsor | Singapore Eye Research Institute |
| Drug class | Prostaglandin analogue, Beta blocker, Carbonic anhydrase inhibitor, Alpha-2 adrenergic agonist |
| Target | Prostaglandin F2α receptor, Beta-adrenergic receptor, Carbonic anhydrase, Alpha-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | Phase 3 |
Mechanism of action
Travoprost, Timolol, Azopt, and Brimonidine work together to reduce intraocular pressure in patients with glaucoma or ocular hypertension. By increasing uveoscleral outflow and decreasing aqueous humor production, these medications help to alleviate symptoms and slow disease progression. The combination of these mechanisms provides a comprehensive approach to managing glaucoma and ocular hypertension.
Approved indications
- Glaucoma, Ocular hypertension
Common side effects
- Headache
- Eye pain
- Blepharitis
- Dry mouth
- Dizziness
Key clinical trials
- Retinal Ganglion Cell Neuroprotection Under Prostaglandin Analogues
- 24-Hour Intraocular Pressure With Brinzolamide/Timolol Versus Brimonidine/Timolol (PHASE4)
- Choroidal Thickness and Its Correlations With Ocular Parameters in Primary Open-angle Glaucoma (PHASE4)
- Safety and Efficacy of SIMBRINZA® BID as an Adjunctive to DUOTRAV® (PHASE4)
- Effect of Prophylactic Aqueous Suppression on Hyperencapsulation of Ahmed Glaucoma Valves (PHASE4)
- Intraocular Pressure (IOP) Lowering Effect of Selective Laser Trabeculoplasty Versus Prostaglandin Analogues in Angle Closure Glaucoma (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Travoprost/ Timolol/ Azopt/ Brimonidine CI brief — competitive landscape report
- Travoprost/ Timolol/ Azopt/ Brimonidine updates RSS · CI watch RSS
- Singapore Eye Research Institute portfolio CI
Frequently asked questions about Travoprost/ Timolol/ Azopt/ Brimonidine
What is Travoprost/ Timolol/ Azopt/ Brimonidine?
How does Travoprost/ Timolol/ Azopt/ Brimonidine work?
What is Travoprost/ Timolol/ Azopt/ Brimonidine used for?
Who makes Travoprost/ Timolol/ Azopt/ Brimonidine?
What drug class is Travoprost/ Timolol/ Azopt/ Brimonidine in?
What development phase is Travoprost/ Timolol/ Azopt/ Brimonidine in?
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Related
- Drug class: All Prostaglandin analogue, Beta blocker, Carbonic anhydrase inhibitor, Alpha-2 adrenergic agonist drugs
- Target: All drugs targeting Prostaglandin F2α receptor, Beta-adrenergic receptor, Carbonic anhydrase, Alpha-2 adrenergic receptor
- Manufacturer: Singapore Eye Research Institute — full pipeline
- Therapeutic area: All drugs in Ophthalmology
- Indication: Drugs for Glaucoma, Ocular hypertension
- Compare: Travoprost/ Timolol/ Azopt/ Brimonidine vs similar drugs
- Pricing: Travoprost/ Timolol/ Azopt/ Brimonidine cost, discount & access