Nicotinic acetylcholine receptor — Drug Target

All drugs that target Nicotinic acetylcholine receptor — marketed and clinical-stage. Includes 7 drug classes acting on this target.

Drug classes

Neuromuscular blocking agent · Non-depolarizing neuromuscular blocking agent · Anticonvulsant · Non-depolarizing neuromuscular blocker · Insecticide · Neuromuscular blocking agent (non-depolarizing) · Cholinergic agent

Marketed (6)

• Extubation U · Seganest · Neuromuscular blocking agent · Anesthesiology
  Extubation U is a neuromuscular blocking agent that facilitates endotracheal tube removal.
• sufficient dose of rocuronium · Korea University Guro Hospital · Non-depolarizing neuromuscular blocking agent · Anesthesia
  Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the nicotinic acetylcholine receptor on the motor endplate, causing muscle paralysis.
• Rocuronium Injectable Solution · Federal University of São Paulo · Non-depolarizing neuromuscular blocking agent · Anesthesia
  Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the nicotinic acetylcholine receptor on the motor endplate, causing muscle paralysis.
• Atracurium, TBW · St. Antonius Hospital · Non-depolarizing neuromuscular blocking agent · Anesthesia
  Atracurium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the neuromuscular junction to produce muscle paralysis.
• Magnesium Sulfate In Dextrose 5% In Plastic Container · Pfizer Inc. · Anticonvulsant
  Magnesium Sulfate blocks neuromuscular transmission and decreases acetylcholine levels, leading to vasodilation and a depressant effect on the central nervous system.
• NIMBEX · Assistance Publique Hopitaux De Marseille · Non-depolarizing neuromuscular blocking agent · Anesthesia
  Nimbex (cisatracurium) is a non-depolarizing neuromuscular blocking agent that competitively inhibits acetylcholine at the neuromuscular junction.

Phase 3 pipeline (11)

• Rocuronium bolus maintenance · Merck Sharp & Dohme LLC · Non-depolarizing neuromuscular blocker · Anesthesiology
  Rocuronium acts as a competitive antagonist at the nicotinic acetylcholine receptor, preventing acetylcholine from binding and thereby inhibiting muscle contraction.
• Repeated rocuronium dose · University Hospital, Antwerp · Non-depolarizing neuromuscular blocking agent · Anesthesiology
  Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively inhibits the nicotinic acetylcholine receptor at the neuromuscular junction.
• spinosad topical suspension, 0.9% · ParaPRO LLC · Insecticide · Entomology
  Spinosad topical suspension works by activating nicotinic acetylcholine receptors in the insect nervous system, ultimately leading to the death of the insect.
• Rocuronium emergency surgery · Diskapi Yildirim Beyazit Education and Research Hospital · Neuromuscular blocking agent (non-depolarizing) · Anesthesia
  Rocuronium is a neuromuscular blocking agent that competitively binds to acetylcholine receptors at the neuromuscular junction, preventing muscle contraction.
• Rocuronium elective surgery · Diskapi Yildirim Beyazit Education and Research Hospital · Non-depolarizing neuromuscular blocking agent · Anesthesiology
  Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the nicotinic acetylcholine receptor on the motor endplate.
• rocuronium continuous infusion maintenance · Merck Sharp & Dohme LLC · Non-depolarizing neuromuscular blocker · Anesthesiology
  Rocuronium acts as a competitive antagonist at the nicotinic acetylcholine receptor, preventing acetylcholine from binding and thereby inhibiting muscle contraction.
• Rocuronium bromide (Zemuron) · Merck Sharp & Dohme LLC · Non-depolarizing neuromuscular blocking agent · Anesthesiology
  Rocuronium bromide is a non-depolarizing neuromuscular blocking agent that competitively inhibits the nicotinic acetylcholine receptor at the neuromuscular junction.
• Single rocuronium dose · University Hospital, Antwerp · Non-depolarizing neuromuscular blocking agent · Anesthesiology
  Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively inhibits the nicotinic acetylcholine receptor at the neuromuscular junction.
• Rocuronium 0.8 · Ain Shams University · Non-depolarizing neuromuscular blocking agent · Anesthesiology
  Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively inhibits nicotinic acetylcholine receptors at the neuromuscular junction.
• Rocuronium bromide (Org 9426) · Merck Sharp & Dohme LLC · Non-depolarizing neuromuscular blocking agent · Anesthesiology
  Rocuronium bromide is a non-depolarizing neuromuscular blocking agent that competitively inhibits the nicotinic acetylcholine receptor at the neuromuscular junction.
• Rocuronium 1.2 · Ain Shams University · Non-depolarizing neuromuscular blocking agent · Anesthesiology
  Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the nicotinic acetylcholine receptor on the motor endplate.

Phase 2 pipeline (1)

• Iontophoresis with acetylcholine delivery · Assistance Publique - Hôpitaux de Paris · Cholinergic agent · Neurology
  Acetylcholine delivery via iontophoresis stimulates nicotinic acetylcholine receptors.