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Rocuronium emergency surgery
Rocuronium is a neuromuscular blocking agent that competitively binds to acetylcholine receptors at the neuromuscular junction, preventing muscle contraction.
Rocuronium is a neuromuscular blocking agent that competitively binds to acetylcholine receptors at the neuromuscular junction, preventing muscle contraction. Used for Neuromuscular blockade for emergency surgery and rapid sequence intubation, Facilitation of endotracheal intubation during anesthesia.
At a glance
| Generic name | Rocuronium emergency surgery |
|---|---|
| Also known as | esmeron |
| Sponsor | Diskapi Yildirim Beyazit Education and Research Hospital |
| Drug class | Neuromuscular blocking agent (non-depolarizing) |
| Target | Nicotinic acetylcholine receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | Phase 3 |
Mechanism of action
Rocuronium is a non-depolarizing steroidal neuromuscular blocker that acts as a competitive antagonist at the nicotinic acetylcholine receptors on the motor end plate. By blocking acetylcholine from binding to these receptors, it prevents depolarization and muscle contraction, producing paralysis necessary for intubation and surgical procedures. Its onset is rapid (60-90 seconds) and duration is intermediate (30-40 minutes), making it suitable for emergency surgical settings.
Approved indications
- Neuromuscular blockade for emergency surgery and rapid sequence intubation
- Facilitation of endotracheal intubation during anesthesia
Common side effects
- Prolonged neuromuscular blockade
- Histamine release (flushing, hypotension)
- Anaphylaxis
- Residual paralysis
Key clinical trials
- Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. (NA)
- Comparison of Airway Management With Bronchial Blocker and Double-Lumen Tube in Single-Lung Ventilation (NA)
- The Effect Of Positive End-Expiratory Pressure on Optic Nerve Sheath Diameter In Pediatric Patients Undergoing Craniotomy in Supine Position (NA)
- Investigation of the Optimum PEEP Mechanical Power Relationship
- Minimal Flow Anesthesia and Infection Risk (NA)
- Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery (NA)
- Hemodynamic Effects of Apnoeic Oxygenation With High-flow Nasal Oxygen in Adults Undergoing Laryngeal Surgery (NA)
- Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |