{"id":"rocuronium-emergency-surgery","safety":{"commonSideEffects":[{"rate":null,"effect":"Prolonged neuromuscular blockade"},{"rate":"rare","effect":"Histamine release (flushing, hypotension)"},{"rate":"<0.1","effect":"Anaphylaxis"},{"rate":null,"effect":"Residual paralysis"}]},"_chembl":{"chemblId":"CHEMBL1200648","moleculeType":"Small molecule","molecularWeight":"609.69"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Rocuronium is a non-depolarizing steroidal neuromuscular blocker that acts as a competitive antagonist at the nicotinic acetylcholine receptors on the motor end plate. By blocking acetylcholine from binding to these receptors, it prevents depolarization and muscle contraction, producing paralysis necessary for intubation and surgical procedures. Its onset is rapid (60-90 seconds) and duration is intermediate (30-40 minutes), making it suitable for emergency surgical settings.","oneSentence":"Rocuronium is a neuromuscular blocking agent that competitively binds to acetylcholine receptors at the neuromuscular junction, preventing muscle contraction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:32:34.581Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuromuscular blockade for emergency surgery and rapid sequence intubation"},{"name":"Facilitation of endotracheal intubation during anesthesia"}]},"trialDetails":[{"nctId":"NCT07486336","phase":"NA","title":"Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.","status":"NOT_YET_RECRUITING","sponsor":"Ente Ospedaliero Ospedali Galliera","startDate":"2026-09-01","conditions":"Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction 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Spontaneous Breathing for VATS","status":"RECRUITING","sponsor":"Tongji Hospital","startDate":"2024-10-01","conditions":"Video-assisted Thoracoscopic Lung Surgery；Anesthesia","enrollment":480},{"nctId":"NCT06343259","phase":"NA","title":"The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury","status":"RECRUITING","sponsor":"Sisli Hamidiye Etfal Training and Research Hospital","startDate":"2024-04-05","conditions":"Myocardial Injury After Non-cardiac Surgery, Hypotension During Surgery, Anesthesia, General","enrollment":100},{"nctId":"NCT05341154","phase":"NA","title":"Ketamine Versus Dexmedetomidine for Prevention of Postoperative Delirium","status":"COMPLETED","sponsor":"Huda Fahmy Mahmoud, PhD","startDate":"2021-12-01","conditions":"Emergence Delirium","enrollment":60},{"nctId":"NCT02634255","phase":"PHASE3","title":"The Onset Time of Rocuronium in Emergency and Elective Surgery","status":"UNKNOWN","sponsor":"Diskapi Yildirim Beyazit Education and 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to acetylcholine receptors at the neuromuscular junction, preventing muscle contraction. Used for Neuromuscular blockade for emergency surgery and rapid sequence intubation, Facilitation of endotracheal intubation during anesthesia.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}