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NIMBEX
Nimbex (cisatracurium) is a non-depolarizing neuromuscular blocking agent that competitively inhibits acetylcholine at the neuromuscular junction.
Nimbex (cisatracurium) is a non-depolarizing neuromuscular blocking agent that competitively inhibits acetylcholine at the neuromuscular junction to produce skeletal muscle paralysis. Used for Skeletal muscle relaxation during anesthesia for intubation and surgery, Mechanical ventilation in intensive care settings.
At a glance
| Generic name | NIMBEX |
|---|---|
| Sponsor | Assistance Publique Hopitaux De Marseille |
| Drug class | Non-depolarizing neuromuscular blocking agent |
| Target | Nicotinic acetylcholine receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Cisatracurium binds to nicotinic acetylcholine receptors at the motor end plate, preventing acetylcholine from binding and thereby blocking neuromuscular transmission. This results in muscle paralysis used during anesthesia and mechanical ventilation. It undergoes Hofmann elimination and ester hydrolysis, making it suitable for patients with hepatic or renal impairment.
Approved indications
- Muscle relaxation during anesthesia for intubation and surgery
- Facilitation of mechanical ventilation in intensive care units
Common side effects
- Histamine release (flushing, hypotension, tachycardia)
- Prolonged neuromuscular blockade
- Anaphylaxis
Key clinical trials
- Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation (NA)
- Safety and Efficacy of HRS-9190 Compared to Cisatracurium for Continuous Intravenous Infusion in Adults (PHASE2)
- Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease (PHASE4)
- Continuous Versus 1-min Oscillometric Arterial BP Monitoring (NA)
- Tubeless Spontaneous Ventilation Anesthesia in Kidney Transplantation (NA)
- Partial Neuromuscular Blockade in Acute Hypoxemic Respiratory Failure (NA)
- Differences in Speed of Recovery From Anesthesia for Intraoral Surgery (NA)
- Comparison for the Effect of Neuromuscular Blocking Agents Versus Sedation Alone on Severe ARDS Patients Due to COVID-19 (NA)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |