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Rocuronium elective surgery
Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the nicotinic acetylcholine receptor on the motor endplate.
Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the nicotinic acetylcholine receptor on the motor endplate. Used for Muscle relaxation during elective surgery under general anesthesia, Facilitation of endotracheal intubation.
At a glance
| Generic name | Rocuronium elective surgery |
|---|---|
| Also known as | esmeron |
| Sponsor | Diskapi Yildirim Beyazit Education and Research Hospital |
| Drug class | Non-depolarizing neuromuscular blocking agent |
| Target | Nicotinic acetylcholine receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Rocuronium binds to nicotinic acetylcholine receptors at the neuromuscular junction, preventing acetylcholine from binding and causing muscle depolarization. This results in paralysis of skeletal muscles, which is used during anesthesia to facilitate intubation and maintain muscle relaxation during surgery. The drug's effects are reversible and can be antagonized by acetylcholinesterase inhibitors or newer agents like sugammadex.
Approved indications
- Muscle relaxation during elective surgery under general anesthesia
- Facilitation of endotracheal intubation
Common side effects
- Prolonged neuromuscular blockade
- Histamine release (flushing, hypotension)
- Anaphylaxis
- Postoperative residual curarization
Key clinical trials
- Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. (NA)
- Safety and Efficacy of HRS-9190 Compared to Rocuronium for Bolus Maintenance in Adults (PHASE2)
- The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery (PHASE4)
- Cardiac Output and Recovery Time (NA)
- Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation in Adults (PHASE2)
- TetraGraph in Rocuronium Infusions (NA)
- Optic Nerve Sheath Diameter and Postoperative Cognitive Disfunction at Laparoscopic Surgery
- Two Video Laryngoscopes (Laringocel® and C-MAC®) for First-Attempt Intubation in Adults Undergoing Elective Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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