{"id":"rocuronium-elective-surgery","safety":{"commonSideEffects":[{"rate":null,"effect":"Prolonged neuromuscular blockade"},{"rate":null,"effect":"Histamine release (flushing, hypotension)"},{"rate":null,"effect":"Anaphylaxis"},{"rate":null,"effect":"Postoperative residual curarization"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Rocuronium binds to nicotinic acetylcholine receptors at the neuromuscular junction, preventing acetylcholine from binding and causing muscle depolarization. This results in paralysis of skeletal muscles, which is used during anesthesia to facilitate intubation and maintain muscle relaxation during surgery. The drug's effects are reversible and can be antagonized by acetylcholinesterase inhibitors or newer agents like sugammadex.","oneSentence":"Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the nicotinic acetylcholine receptor on the motor endplate.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:32:37.190Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Muscle relaxation during elective surgery under general anesthesia"},{"name":"Facilitation of endotracheal intubation"}]},"trialDetails":[{"nctId":"NCT07486336","phase":"NA","title":"Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.","status":"NOT_YET_RECRUITING","sponsor":"Ente Ospedaliero Ospedali Galliera","startDate":"2026-09-01","conditions":"Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)","enrollment":100},{"nctId":"NCT07404579","phase":"PHASE2","title":"Safety and Efficacy of HRS-9190 Compared to Rocuronium for Bolus Maintenance in Adults","status":"RECRUITING","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2026-03-06","conditions":"Neuromuscular Blockade","enrollment":90},{"nctId":"NCT06349057","phase":"PHASE4","title":"The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2024-01-01","conditions":"Postoperative Recovery, Length of Hospital Stay, Postoperative Complications","enrollment":120},{"nctId":"NCT04619225","phase":"NA","title":"Cardiac Output and Recovery Time","status":"TERMINATED","sponsor":"Mayo Clinic","startDate":"2022-09-14","conditions":"Residual Neuromuscular Blockade","enrollment":7},{"nctId":"NCT07252921","phase":"PHASE2","title":"Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation in Adults","status":"COMPLETED","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2025-10-30","conditions":"Neuromuscular Blockade","enrollment":70},{"nctId":"NCT06472284","phase":"NA","title":"TetraGraph in Rocuronium Infusions","status":"ACTIVE_NOT_RECRUITING","sponsor":"Joseph D. 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