Retinoid

This page covers all Retinoid drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Retinoic acid receptor RXR-gamma, Retinoid acid receptors (RAR and RXR), Retinoic acid receptors (RAR-alpha, RAR-beta, RAR-gamma).

Targets

Retinoic acid receptor RXR-gamma · Retinoid acid receptors (RAR and RXR) · Retinoic acid receptors (RAR-alpha, RAR-beta, RAR-gamma) · Retinoic acid receptors (RAR-α, RAR-β, RAR-γ) · Retinoid X receptor (RXR), Retinoid acid receptor (RAR) · Retinoid X Receptor (RXR), Retinoid Acid Receptor (RAR) · Retinoid acid receptors (RAR), Retinoid X receptors (RXR) · Retinoic acid receptor gamma (RAR-γ) · Retinoic acid receptor gamma (RARγ) · Retinoid nuclear receptors (RAR and RXR)

Marketed (18)

• Tegison · Immunology
• isotretinoin (Roaccutane) · Premier Specialists, Australia · Dermatology
  Isotretinoin is a potent retinoid that reduces sebaceous gland size and sebum production, and has anti-inflammatory and anti-proliferative effects on skin cells.
• Tretinoin cream 0.05 · Massachusetts General Hospital · Dermatology
  Tretinoin is a vitamin A derivative that binds to retinoic acid receptors in the nucleus, promoting cell differentiation and reducing sebum production and comedone formation.
• Tretinoin Gel (tretinoin) · Stiefel, a GSK Company · Dermatology
  Tretinoin is a vitamin A derivative that binds to retinoic acid receptors in skin cells to promote cell turnover, reduce sebum production, and normalize keratinization.
• Tretinoin 0.05% · Pontificia Universidad Catolica de Chile · Dermatology
  Tretinoin is a retinoid that binds to retinoic acid receptors to regulate gene expression, promoting cell differentiation and reducing sebum production and comedone formation.
• tretinoin 0.025% cream · Wake Forest University · Dermatology
  Tretinoin is a vitamin A derivative that binds to retinoic acid receptors to regulate gene expression, promoting cell differentiation and reducing sebum production and comedone formation.
• Tretinoin gel · Bausch Health Americas, Inc. · Dermatology
  Tretinoin is a vitamin A derivative that binds to retinoic acid receptors in the nucleus, promoting cell differentiation and reducing sebum production and comedone formation.
• Tazarotene 0.1% gel · Galderma R&D · Dermatology
  Tazarotene is a retinoid that binds to retinoid X receptors (RXR) and retinoid acid receptors (RAR) to regulate gene expression and promote skin cell differentiation and turnover.
• Acitretin (also called U0279) · Stiefel, a GSK Company · Dermatology
  Acitretin is a retinoid that binds to retinoid receptors in the nucleus, modulating gene expression to reduce keratinocyte proliferation and promote differentiation.
• Acitretin Capsules. · Army Medical University, China · Dermatology
  Acitretin is a retinoid that binds to retinoid receptors to regulate the growth, differentiation, and keratinization of epithelial cells.
• oral isotretinoin · Federal University of São Paulo · Dermatology
  Isotretinoin is a potent retinoid that binds to nuclear retinoid receptors to regulate gene expression, reducing sebum production and normalizing epithelial cell differentiation in the skin.
• Adapalene Gel · Bausch Health Americas, Inc. · Dermatology
  Adapalene is a third-generation retinoid that binds to retinoic acid receptors to normalize skin cell differentiation and reduce inflammation.
• Tazarotene 0.045% Lotion · Dr. Emmy Graber · Dermatology
  Tazarotene is a retinoid that binds to retinoid receptors to regulate gene expression and reduce skin inflammation and abnormal keratinocyte differentiation.
• Topical Adapalene Gel 0.1% · University of Louisville · Dermatology
  Adapalene is a third-generation retinoid that binds to retinoic acid receptors to normalize skin cell differentiation and reduce inflammation in acne.
• Tazarotene Cream, 0.1% · Galderma R&D · Dermatology
  Tazarotene is a retinoid that binds to retinoid X receptors (RXR) and retinoid acid receptors (RAR) to regulate gene expression and reduce skin inflammation and abnormal keratinocyte differentiation.
• Tretinoin cream 0.005% · Hexsel Dermatology Clinic · Dermatology
  Tretinoin is a retinoid that binds to retinoic acid receptors in skin cells to promote cell turnover, reduce sebum production, and normalize keratinization.
• Retin-A Micro Microsphere 0.1% · Galderma R&D · Dermatology
  Retin-A Micro delivers tretinoin (a vitamin A derivative) in microsphere form to normalize skin cell turnover and reduce comedone formation.
• acoltremon 0.003% · Center for Sight Las Vegas · Ophthalmology
  Acoltremon is a topical retinoid that modulates retinoid receptor signaling to promote corneal epithelial healing and reduce inflammation.

Phase 3 pipeline (21)

• Tazarotene (Actavis) · Actavis Inc. · Dermatology
  Tazarotene is a retinoid that binds to retinoid X receptors (RXR) and retinoid acid receptors (RAR) to regulate gene expression and promote skin cell differentiation and turnover.
• Tazorac Cream, 0.1% · Dr. Reddy's Laboratories Limited · Dermatology
  Tazarotene is a retinoid that binds to retinoid receptors to regulate cell differentiation and reduce inflammation in the skin.
• Adapalene 0,1% cream · Dr.dr.Irma Bernadette, SpKK (K) · Dermatology
  Adapalene is a third-generation retinoid that binds to retinoic acid receptors to normalize skin cell differentiation and reduce inflammation.
• CIP-Isotretinoin · Cipher Pharmaceuticals Inc. · Oncology
  CIP-Isotretinoin is a retinoid that binds to nuclear retinoid receptors to regulate gene expression and promote differentiation and apoptosis of abnormal cells.
• Isotretinoin capsules · Centro Dermatológico Dr. Ladislao de la Pascua · Dermatology
  Isotretinoin is a potent retinoid that reduces sebaceous gland size and sebum production while normalizing epithelial cell differentiation in the skin.
• Solaraze 3% Topical Gel · Encube Ethicals Pvt. Ltd. · Dermatology
  Solaraze 3% Topical Gel is a topical gel formulation of tazarotene, a retinoid that modulates the expression of genes involved in cell proliferation and differentiation.
• Reference: Tazorac Cream, 0.05% · G & W Laboratories Inc. · Dermatology
  Tazorac Cream, 0.05% is a topical retinoid that works by promoting cell turnover and preventing the formation of comedones, thereby reducing acne severity.
• S5G4T-2 · Sol-Gel Technologies, Ltd. · Dermatology
  S5G4T-2 is a topical gel formulation of a retinoid, which works by modulating the activity of retinoic acid receptors in the skin.
• adapalene lotion 0.1% · Galderma R&D · Dermatology
  Adapalene is a topical retinoid that works by binding to retinoic acid receptors, modulating gene expression and promoting cell turnover.
• Tazarotene Foam · Stiefel, a GSK Company · Dermatology
  Tazarotene Foam is a topical retinoid that modulates cell growth and differentiation.
• CD07805/47 gel 0.5%/CD07805/47 Vehicle · Galderma R&D · Dermatology
  CD07805/47 is a topical retinoid that modulates retinoid receptor signaling to reduce inflammation and promote skin cell differentiation in dermatological conditions.
• NIK-333(peretinoin) · Kowa Company, Ltd. · Oncology
  NIK-333 (peretinoin) is a synthetic retinoid that acts as a retinoic acid receptor agonist.
• Tazarotene (Fabior™) · Actavis Inc. · Dermatology
  Tazarotene is a topical retinoid that modulates the expression of genes involved in cell proliferation and differentiation.
• tretinoin 0.05% emollient cream · Galderma R&D · Dermatology
  Tretinoin is a retinoid that promotes skin cell turnover and reduces acne by unclogging pores.
• Trifarotene 0.005 % Topical Cream · Teva Pharmaceuticals USA · Dermatology
  Trifarotene is a retinoic acid receptor gamma (RAR-gamma) agonist that modulates the expression of genes involved in cell differentiation and proliferation.
• CD07805/47 gel · Galderma R&D · Dermatology
  CD07805/47 gel is a topical retinoid that modulates skin cell differentiation and reduces inflammation for acne treatment.
• LEO43204 gel · LEO Pharma · Dermatology
  LEO43204 is a topical retinoid that modulates retinoid receptor signaling to reduce inflammation and promote skin cell differentiation in dermatological conditions.
• Drug: CD07805/47 gel · Galderma R&D · Dermatology
  CD07805/47 gel is a topical retinoid that promotes skin cell turnover and collagen remodeling to improve signs of photoaging and wrinkles.
• IDP-120 Gel · Bausch Health Americas, Inc. · Dermatology
  IDP-120 Gel is a topical retinoid formulation designed to treat acne and other skin conditions by promoting cell turnover and reducing sebum production.
• IDP-126 Gel · Bausch Health Americas, Inc. · Dermatology
  IDP-126 is a topical retinoid that modulates retinoid receptor signaling to reduce inflammation and promote skin cell differentiation in dermatological conditions.
• Tazarotene Cream 0.05% · Fougera Pharmaceuticals Inc. · Dermatology
  Tazarotene is a topical retinoid that modulates cell growth and differentiation.

Phase 2 pipeline (3)

• Fenretinide Lym-X-Sorb Oral Powder · South Plains Oncology Consortium · Oncology
  Fenretinide is a synthetic retinoid that induces apoptosis in cancer cells.
• CD1579 5% · Galderma R&D · Dermatology
  CD1579 5% is a topical retinoid that modulates cell growth and differentiation.
• CD11301 0.06% · Galderma R&D · Dermatology
  CD11301 is a topical retinoid that modulates the retinoic acid pathway to treat acne.