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Tretinoin cream 0.005%
Tretinoin is a retinoid that binds to retinoic acid receptors in skin cells to promote cell turnover, reduce sebum production, and normalize keratinization.
Tretinoin is a retinoid that binds to retinoic acid receptors in skin cells to promote cell turnover, reduce sebum production, and normalize keratinization. Used for Acne vulgaris, Photoaging and fine wrinkles, Hyperpigmentation.
At a glance
| Generic name | Tretinoin cream 0.005% |
|---|---|
| Also known as | (Vitanol A, Stiefel) |
| Sponsor | Hexsel Dermatology Clinic |
| Drug class | Retinoid |
| Target | Retinoic acid receptors (RAR-α, RAR-β, RAR-γ) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Tretinoin activates nuclear retinoic acid receptors (RAR-α, RAR-β, RAR-γ), which regulate gene expression involved in cell differentiation and proliferation. This leads to increased epidermal cell turnover, reduced comedone formation, and decreased sebaceous gland activity. The drug also has anti-inflammatory properties and stimulates collagen remodeling, making it effective for acne and photoaging.
Approved indications
- Acne vulgaris
- Photoaging and fine wrinkles
- Hyperpigmentation
Common side effects
- Erythema and irritation
- Peeling and dryness
- Photosensitivity
- Burning or stinging
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |