{"id":"tretinoin-cream-0-005","safety":{"commonSideEffects":[{"rate":"40-60","effect":"Erythema and irritation"},{"rate":"30-50","effect":"Peeling and dryness"},{"rate":"10-20","effect":"Photosensitivity"},{"rate":"20-40","effect":"Burning or stinging"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tretinoin activates nuclear retinoic acid receptors (RAR-α, RAR-β, RAR-γ), which regulate gene expression involved in cell differentiation and proliferation. This leads to increased epidermal cell turnover, reduced comedone formation, and decreased sebaceous gland activity. The drug also has anti-inflammatory properties and stimulates collagen remodeling, making it effective for acne and photoaging.","oneSentence":"Tretinoin is a retinoid that binds to retinoic acid receptors in skin cells to promote cell turnover, reduce sebum production, and normalize keratinization.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:39:07.691Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"},{"name":"Photoaging and fine wrinkles"},{"name":"Hyperpigmentation"}]},"trialDetails":[{"nctId":"NCT01027793","phase":"PHASE4","title":"Trial Comparing Treatment of Tretinoin or Superficial Dermabrasion for Stretch Marks","status":"COMPLETED","sponsor":"Hexsel Dermatology Clinic","startDate":"2009-03","conditions":"Stretch Marks, Striae, Treatment","enrollment":32}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["(Vitanol A, Stiefel)"],"phase":"marketed","status":"active","brandName":"Tretinoin cream 0.005%","genericName":"Tretinoin cream 0.005%","companyName":"Hexsel Dermatology Clinic","companyId":"hexsel-dermatology-clinic","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tretinoin is a retinoid that binds to retinoic acid receptors in skin cells to promote cell turnover, reduce sebum production, and normalize keratinization. Used for Acne vulgaris, Photoaging and fine wrinkles, Hyperpigmentation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}