GnRH receptor — Drug Target
All drugs that target GnRH receptor — marketed and clinical-stage. Includes 5 drug classes acting on this target.
Drug classes
GnRH agonist · GnRH antagonist · GnRH antagonist and GnRH agonist combination · GnRH agonist/antagonist · GnRH receptor antagonist
Marketed (23)
- Leuprolide Depot · Enteris BioPharma Inc. · GnRH agonist · Oncology; Urology; Gynecology
Leuprolide is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production. - Eligard (TM) · Chesapeake Urology Research Associates · GnRH agonist · Oncology
Eligard is a leuprolide acetate depot injection that suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to reduced testosterone production. - Ganirelix Acetate, Cetrolix Acetate · Assaf-Harofeh Medical Center · GnRH antagonist · Reproductive Medicine / Fertility
Ganirelix and Cetrolix are gonadotropin-releasing hormone (GnRH) antagonists that block GnRH receptors to suppress luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion. - cetrorelix (cetrotide) · Eugonia · GnRH antagonist · Reproductive/Fertility
Cetrorelix is a gonadotropin-releasing hormone (GnRH) antagonist that blocks GnRH receptors to suppress luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion. - GnRH analogue (Zoladex) · University of Edinburgh · GnRH agonist · Oncology
Zoladex is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production. - Antagonist GnRH Cetrotide · Instituto Valenciano de Infertilidad, IVI VALENCIA · GnRH antagonist · Reproductive Medicine / Fertility
Cetrotide is a GnRH antagonist that directly blocks gonadotropin-releasing hormone receptors to suppress luteinizing hormone and follicle-stimulating hormone secretion. - GnRH antagonist-Cetrorelix · University of Edinburgh · GnRH antagonist · Reproductive Medicine / Endocrinology
Cetrorelix blocks gonadotropin-releasing hormone (GnRH) receptors to suppress luteinizing hormone and follicle-stimulating hormone secretion. - Lupron Trigger · Weill Medical College of Cornell University · GnRH agonist · Reproductive Medicine / Fertility
Lupron Trigger is a GnRH agonist that causes a surge in luteinizing hormone (LH) to trigger final oocyte maturation and ovulation in assisted reproductive technology cycles. - Cetrorelix and Leuprolide · Instituto Valenciano de Infertilidad, IVI VALENCIA · GnRH antagonist and GnRH agonist combination · Reproductive Medicine / Fertility
Cetrorelix and leuprolide work together to suppress the pituitary-gonadal axis by blocking GnRH signaling, preventing premature luteinizing hormone surge during controlled ovarian hyperstimulation for assisted reproduction. - Gonapeptyl® · University Hospital, Ghent · GnRH agonist · Oncology; Endocrinology
Gonapeptyl is a GnRH (gonadotropin-releasing hormone) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production. - Half-Dose Depot Triptorelin · Tehran University of Medical Sciences · GnRH agonist · Oncology; Endocrinology
Half-dose depot triptorelin is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production. - Leuprorelin Acetate Depot 3M · Takeda · GnRH agonist · Oncology
Leuprorelin acetate is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production. - Leuprolide acetate in depot suspension · Colorado Center for Reproductive Medicine · GnRH agonist · Reproductive Medicine / Endocrinology
Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production. - GnRH agonist trigger · Rambam Health Care Campus · GnRH agonist · Reproductive Medicine / Fertility
GnRH agonist trigger induces a surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to trigger final oocyte maturation and ovulation in assisted reproductive technology cycles. - TRIPTORELIN ACETATE, hCG · HaEmek Medical Center, Israel · GnRH agonist · Reproductive/Fertility
Triptorelin is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production, combined with hCG for fertility preservation or ovarian stimulation. - GnRH agonist/antagonist · Memorial Sloan Kettering Cancer Center · GnRH agonist/antagonist · Oncology
GnRH agonists/antagonists suppress gonadotropin-releasing hormone signaling to reduce sex hormone production, used in oncology to manage hormone-sensitive cancers and their treatment side effects. - Gonadotropin-releasing Hormone Analog · Rutgers, The State University of New Jersey · GnRH agonist · Oncology; Endocrinology
GnRH analogs bind to gonadotropin-releasing hormone receptors in the pituitary gland to suppress the release of luteinizing hormone and follicle-stimulating hormone, thereby reducing sex hormone production. - Degarelix (LHRH antagonist) · Rabin Medical Center · GnRH antagonist · Oncology
Degarelix is a gonadotropin-releasing hormone (GnRH) antagonist that rapidly suppresses luteinizing hormone and follicle-stimulating hormone, leading to testosterone suppression. - Lupron Depot · University of Michigan Rogel Cancer Center · GnRH agonist · Oncology
Lupron Depot is a gonadotropin-releasing hormone (GnRH) agonist that suppresses testosterone and estrogen production by desensitizing the pituitary gland. - Ultra-Long GnRH Agonists · University of Palermo · GnRH agonist · Oncology; Endocrinology
Ultra-long GnRH agonists provide sustained suppression of gonadotropin-releasing hormone signaling, leading to prolonged inhibition of luteinizing hormone and follicle-stimulating hormone release. - Triptorelin pamoate（15mg） · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · GnRH agonist · Oncology; Endocrinology
Triptorelin pamoate is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production. - triptorelin 0.1 · Chong Qing Reproducive and Genetic Institute · GnRH agonist · Oncology, Reproductive Medicine, Endocrinology
Triptorelin is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production. - Antagon ™ · EMD Serono · GnRH antagonist · Reproductive Medicine / Fertility
Antagon is a gonadotropin-releasing hormone (GnRH) antagonist that rapidly suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to prevent premature ovulation during assisted reproductive technology.
Phase 3 pipeline (33)
- Leuprolide Acetate for Injectable Suspension · Oakwood Laboratories, LLC · GnRH agonist · Oncology
Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production. - Leuprolide acetate - Formulation A · Abbott · GnRH agonist · Oncology; Endocrinology
Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production. - Ganirelix (GnRH antagonist) · Instituto Valenciano de Infertilidad, IVI VALENCIA · GnRH antagonist · Reproductive Medicine / Fertility
Ganirelix blocks gonadotropin-releasing hormone (GnRH) receptors to suppress luteinizing hormone (LH) and prevent premature ovulation during assisted reproductive procedures. - TOL2506 · Tolmar Inc. · GnRH agonist · Oncology
TOL2506 is a long-acting leuprolide acetate formulation designed to suppress luteinizing hormone and testosterone levels. - Leuprolide acetate - Formulation B · Abbott · GnRH agonist · Oncology; Endocrinology
Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production. - Leuprorelin acetate · Takeda · GnRH agonist · Oncology
Leuprorelin acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production. - T Leuprolide Injectable Emulsion · Changchun GeneScience Pharmaceutical Co., Ltd. · GnRH agonist · Oncology; Endocrinology
Leuprolide is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production. - TAP-144-SR(3M) · Takeda · GnRH agonist · Oncology
TAP-144-SR is a sustained-release formulation of leuprolide, a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone to reduce sex hormone production. - Triptorelin Pamoate PR 3-month · Ipsen · GnRH agonist · Oncology
Triptorelin Pamoate PR 3-month is a gonadotropin-releasing hormone (GnRH) agonist that works by mimicking the action of the natural hormone GnRH, leading to a decrease in sex hormone production. - Cetrorelix 78+78 · AEterna Zentaris · GnRH antagonist · Oncology; Reproductive/Endocrinology
Cetrorelix is a gonadotropin-releasing hormone (GnRH) antagonist that suppresses luteinizing hormone and follicle-stimulating hormone to inhibit ovarian steroid production. - Leuplin or zoladex · Seoul National University Hospital · GnRH agonist · Oncology
Leuprolide and goserelin are GnRH agonists that suppress luteinizing hormone and follicle-stimulating hormone, leading to suppression of testosterone and estrogen production. - triptorelin, goserelin, leuprorelin · Instituto de Investigación en Oncología Radioterápica - Fundación Española de Oncología Radioterápic · GnRH agonist · Oncology
Triptorelin, goserelin, and leuprorelin are synthetic analogs of gonadotropin-releasing hormone (GnRH) that act as potent agonists, initially stimulating and then downregulating GnRH receptors, leading to a decrease in gonadotropin secretion and subsequently a decrease in sex hormone production. - Relugolix Combination Therapy · Sumitomo Pharma Switzerland GmbH · GnRH antagonist · Oncology
Relugolix is a gonadotropin-releasing hormone (GnRH) antagonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to rapid reduction of testosterone and estrogen levels. - Relugolix CT · University of Michigan · GnRH receptor antagonist · Oncology
Relugolix CT works by inhibiting the activity of gonadotropin-releasing hormone (GnRH) receptors. - Ganirelix 0.25 mg. · Instituto de Investigacion Sanitaria La Fe · GnRH antagonist · Reproductive Medicine / Fertility
Ganirelix is a gonadotropin-releasing hormone (GnRH) antagonist that suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion to prevent premature ovulation during assisted reproductive procedures. - Cetrorelix Pamoate · AEterna Zentaris · GnRH antagonist · Oncology; Reproductive Health
Cetrorelix pamoate is a gonadotropin-releasing hormone (GnRH) antagonist that blocks GnRH receptors to suppress luteinizing hormone and follicle-stimulating hormone secretion. - Relugolix Combination Tablet · Sumitomo Pharma Switzerland GmbH · GnRH receptor antagonist · Oncology
Relugolix combination tablet works by inhibiting gonadotropin-releasing hormone (GnRH) receptors, leading to a decrease in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) production, which in turn reduces testosterone levels. - Triptorelin Injection · Ottawa Hospital Research Institute · GnRH agonist · Oncology
Triptorelin injection is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) that acts as a potent agonist. - Triptorelin for Injection · Changchun GeneScience Pharmaceutical Co., Ltd. · GnRH agonist · Oncology
Triptorelin for Injection is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) that acts as a potent agonist. - Triptorelin Embonate · Marco Lorenzo Bonu · GnRH agonist · Oncology
Triptorelin Embonate is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) that acts as a potent agonist. - Gynodian® Depot (BAY86-5032) · Bayer · GnRH agonist · Endocrinology / Gynecology
Gynodian Depot is a long-acting gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone to reduce estrogen levels. - TAP-144-SR(6M) · Takeda · GnRH agonist · Oncology
TAP-144-SR is a sustained-release formulation of leuprolide, a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone to reduce sex hormone production. - Leuprolide Acetate 3 Month Depot · AbbVie (prior sponsor, Abbott) · GnRH agonist · Oncology; Endocrinology
Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production. - GA Depot · Mapi Pharma Ltd. · GnRH agonist · Oncology, Endocrinology
GA Depot is a long-acting gonadotropin-releasing hormone (GnRH) agonist depot formulation that suppresses luteinizing hormone and follicle-stimulating hormone secretion. - Leuprorelin Acetate Microspheres for Injection · Changchun GeneScience Pharmaceutical Co., Ltd. · GnRH agonist · Oncology; Endocrinology
Leuprorelin acetate is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production. - Leuprolide Acetate (LA) · AbbVie · GnRH agonist · Oncology
Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production. - Cetrotide Injectable Product · El Shatby University Hospital for Obstetrics and Gynecology · GnRH antagonist · Reproductive/Fertility
Cetrotide is a gonadotropin-releasing hormone (GnRH) antagonist that blocks GnRH receptors to suppress luteinizing hormone and follicle-stimulating hormone secretion. - GnRH Agonist (Lupron Depot) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · GnRH agonist · Endocrinology; Oncology; Urology
Lupron Depot is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production. - Gonadotrophin Releasing Hormone · NRG Oncology · GnRH agonist · Oncology
Gonadotropin-releasing hormone (GnRH) agonists stimulate the pituitary gland to release luteinizing hormone and follicle-stimulating hormone, which initially increases sex hormone production before causing downregulation and suppression of testosterone and estrogen. - SHR7280；Ganirelix Acetate Injection simulant · Jiangsu HengRui Medicine Co., Ltd. · GnRH antagonist · Reproductive/Fertility
Ganirelix acetate is a gonadotropin-releasing hormone (GnRH) antagonist that suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion. - Triptorelin Acetate PR 1-month · Ipsen · GnRH agonist · Oncology; Endocrinology
Triptorelin is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production. - KLH-2109 Placebo + Leurprorelin acetate · JW Pharmaceutical · GnRH agonist · Oncology
Leuprorelin acetate is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production. - SHR7280 simulant； Ganirelix Acetate Injection · Jiangsu HengRui Medicine Co., Ltd. · GnRH antagonist · Reproductive Medicine / Fertility
Ganirelix acetate is a gonadotropin-releasing hormone (GnRH) antagonist that suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion.
Phase 2 pipeline (2)
- Goserelin, Histrelin, Leuprolide & Triptorelin · VA Office of Research and Development · GnRH agonist · Oncology
Goserelin, Histrelin, Leuprolide, and Triptorelin are gonadotropin-releasing hormone (GnRH) agonists that work by mimicking the action of natural GnRH to suppress the production of sex hormones. - Degarelix & Relugolix · VA Office of Research and Development · GnRH receptor antagonist · Oncology
Degarelix and Relugolix are GnRH receptor antagonists that inhibit the production of gonadotropin-releasing hormone, leading to a decrease in testosterone levels.