What are GnRH agonist drugs?

GnRH agonist drugs are pharmacologic agents that share a common mechanism (typically targeting GnRH receptor). 17 are currently marketed, with 27 more in clinical development.

What are the marketed GnRH agonist drugs?

Marketed GnRH agonist drugs include Triptorelin pamoate（15mg）, GnRH analogue (Zoladex), Triptorelin (GnRH agonists), Leuprolide (GnRH agonists), Half-Dose Depot Triptorelin, Leuprolide Depot.

GnRH agonist

17 marketed 26 in Phase 3 1 in Phase 2

This page covers all GnRH agonist drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting GnRH receptor, GnRH receptor (GNRHR).

Targets

GnRH receptor · GnRH receptor (GNRHR)

Marketed (17)

Triptorelin pamoate（15mg） · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Oncology; Endocrinology
Triptorelin pamoate is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production.
GnRH analogue (Zoladex) · University of Edinburgh · Oncology
Zoladex is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production.
Triptorelin (GnRH agonists) · University of Pisa · Oncology, Endocrinology
Triptorelin is a GnRH agonist that stimulates the pituitary gland to release luteinizing hormone and follicle-stimulating hormone, initially increasing sex hormone levels before causing sustained suppression through receptor desensitization.
Leuprolide (GnRH agonists) · University of Pisa · Oncology; Endocrinology
Leuprolide is a GnRH agonist that initially stimulates, then suppresses gonadotropin release, leading to decreased testosterone and estrogen production.
Half-Dose Depot Triptorelin · Tehran University of Medical Sciences · Oncology; Endocrinology
Half-dose depot triptorelin is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production.
Leuprolide Depot · Enteris BioPharma Inc. · Oncology; Urology; Gynecology
Leuprolide is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production.
Leuprorelin Acetate Depot 3M · Takeda · Oncology
Leuprorelin acetate is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production.
Lupron Depot · University of Michigan Rogel Cancer Center · Oncology
Lupron Depot is a gonadotropin-releasing hormone (GnRH) agonist that suppresses testosterone and estrogen production by desensitizing the pituitary gland.
Gonadotropin-releasing Hormone Analog · Rutgers, The State University of New Jersey · Oncology; Endocrinology
GnRH analogs bind to gonadotropin-releasing hormone receptors in the pituitary gland to suppress the release of luteinizing hormone and follicle-stimulating hormone, thereby reducing sex hormone production.
Eligard (TM) · Chesapeake Urology Research Associates · Oncology
Eligard is a leuprolide acetate depot injection that suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to reduced testosterone production.
Gonapeptyl® · University Hospital, Ghent · Oncology; Endocrinology
Gonapeptyl is a GnRH (gonadotropin-releasing hormone) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production.
triptorelin 0.1 · Chong Qing Reproducive and Genetic Institute · Oncology, Reproductive Medicine, Endocrinology
Triptorelin is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production.
Leuprolide acetate in depot suspension · Colorado Center for Reproductive Medicine · Reproductive Medicine / Endocrinology
Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production.
Lupron Trigger · Weill Medical College of Cornell University · Reproductive Medicine / Fertility
Lupron Trigger is a GnRH agonist that causes a surge in luteinizing hormone (LH) to trigger final oocyte maturation and ovulation in assisted reproductive technology cycles.
Ultra-Long GnRH Agonists · University of Palermo · Oncology; Endocrinology
Ultra-long GnRH agonists provide sustained suppression of gonadotropin-releasing hormone signaling, leading to prolonged inhibition of luteinizing hormone and follicle-stimulating hormone release.
GnRH agonist trigger · Rambam Health Care Campus · Reproductive Medicine / Fertility
GnRH agonist trigger induces a surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to trigger final oocyte maturation and ovulation in assisted reproductive technology cycles.
TRIPTORELIN ACETATE, hCG · HaEmek Medical Center, Israel · Reproductive/Fertility
Triptorelin is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production, combined with hCG for fertility preservation or ovarian stimulation.

Phase 3 pipeline (26)

GnRH agonist (triptorelin) · Taipei Veterans General Hospital, Taiwan · Oncology
Triptorelin is a GnRH agonist that stimulates the pituitary gland to release luteinizing hormone and follicle-stimulating hormone, initially increasing sex hormone levels before causing desensitization and suppression of testosterone and estrogen production.
triptorelin, goserelin, leuprorelin · Instituto de Investigación en Oncología Radioterápica - Fundación Española de Oncología Radioterápic · Oncology
Triptorelin, goserelin, and leuprorelin are synthetic analogs of gonadotropin-releasing hormone (GnRH) that act as potent agonists, initially stimulating and then downregulating GnRH receptors, leading to a decrease in gonadotropin secretion and subsequently a decrease in sex hormone production.
Leuprolide acetate - Formulation A · Abbott · Oncology; Endocrinology
Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production.
Triptorelin Acetate PR 1-month · Ipsen · Oncology; Endocrinology
Triptorelin is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production.
Triptorelin Injection · Ottawa Hospital Research Institute · Oncology
Triptorelin injection is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) that acts as a potent agonist.
Triptorelin for Injection · Changchun GeneScience Pharmaceutical Co., Ltd. · Oncology
Triptorelin for Injection is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) that acts as a potent agonist.
Leuprolide acetate - Formulation B · Abbott · Oncology; Endocrinology
Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production.
Leuprorelin acetate · Takeda · Oncology
Leuprorelin acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production.
Gynodian® Depot (BAY86-5032) · Bayer · Endocrinology / Gynecology
Gynodian Depot is a long-acting gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone to reduce estrogen levels.
GnRH Agonist (Lupron Depot) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Endocrinology; Oncology; Urology
Lupron Depot is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production.
TAP-144-SR(6M) · Takeda · Oncology
TAP-144-SR is a sustained-release formulation of leuprolide, a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone to reduce sex hormone production.
GA Depot · Mapi Pharma Ltd. · Oncology, Endocrinology
GA Depot is a long-acting gonadotropin-releasing hormone (GnRH) agonist depot formulation that suppresses luteinizing hormone and follicle-stimulating hormone secretion.
Triptorelin (I.N.N.) · Ipsen · Oncology; Endocrinology
Triptorelin is a GnRH agonist that stimulates the pituitary gland to release luteinizing hormone and follicle-stimulating hormone, initially increasing sex hormone levels before causing sustained suppression through receptor desensitization.
Triptorelin Pamoate PR 3-month · Ipsen · Oncology
Triptorelin Pamoate PR 3-month is a gonadotropin-releasing hormone (GnRH) agonist that works by mimicking the action of the natural hormone GnRH, leading to a decrease in sex hormone production.
Leuplin or zoladex · Seoul National University Hospital · Oncology
Leuprolide and goserelin are GnRH agonists that suppress luteinizing hormone and follicle-stimulating hormone, leading to suppression of testosterone and estrogen production.
T Leuprolide Injectable Emulsion · Changchun GeneScience Pharmaceutical Co., Ltd. · Oncology; Endocrinology
Leuprolide is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production.
Triptorelin Embonate · Marco Lorenzo Bonu · Oncology
Triptorelin Embonate is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) that acts as a potent agonist.
TAP-144-SR(3M) · Takeda · Oncology
TAP-144-SR is a sustained-release formulation of leuprolide, a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone to reduce sex hormone production.
Lupron (leuprolide acetate) · Abbott · Oncology
Leuprolide is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production.
KLH-2109 Placebo + Leurprorelin acetate · JW Pharmaceutical · Oncology
Leuprorelin acetate is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to reduced sex hormone production.
TOL2506 · Tolmar Inc. · Oncology
TOL2506 is a long-acting leuprolide acetate formulation designed to suppress luteinizing hormone and testosterone levels.
Leuprolide Acetate (LA) · AbbVie · Oncology
Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production.
Leuprolide Acetate for Injectable Suspension · Oakwood Laboratories, LLC · Oncology
Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production.
Leuprolide Acetate 3 Month Depot · AbbVie (prior sponsor, Abbott) · Oncology; Endocrinology
Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production.
Leuprorelin Acetate Microspheres for Injection · Changchun GeneScience Pharmaceutical Co., Ltd. · Oncology; Endocrinology
Leuprorelin acetate is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production.
Gonadotrophin Releasing Hormone · NRG Oncology · Oncology
Gonadotropin-releasing hormone (GnRH) agonists stimulate the pituitary gland to release luteinizing hormone and follicle-stimulating hormone, which initially increases sex hormone production before causing downregulation and suppression of testosterone and estrogen.

Phase 2 pipeline (1)

Goserelin, Histrelin, Leuprolide & Triptorelin · VA Office of Research and Development · Oncology
Goserelin, Histrelin, Leuprolide, and Triptorelin are gonadotropin-releasing hormone (GnRH) agonists that work by mimicking the action of natural GnRH to suppress the production of sex hormones.