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Cetrorelix Pamoate
Cetrorelix pamoate is a gonadotropin-releasing hormone (GnRH) antagonist that blocks GnRH receptors to suppress luteinizing hormone and follicle-stimulating hormone secretion.
Cetrorelix pamoate is a gonadotropin-releasing hormone (GnRH) antagonist that blocks GnRH receptors to suppress luteinizing hormone and follicle-stimulating hormone secretion. Used for Prostate cancer (hormone-dependent), Ovarian suppression in assisted reproductive technology.
At a glance
| Generic name | Cetrorelix Pamoate |
|---|---|
| Also known as | Cetrorelix pamoate, D-20762, AEZS-102 |
| Sponsor | AEterna Zentaris |
| Drug class | GnRH antagonist |
| Target | GnRH receptor |
| Modality | Small molecule |
| Therapeutic area | Oncology; Reproductive Health |
| Phase | Phase 3 |
Mechanism of action
By antagonizing GnRH receptors in the pituitary gland, cetrorelix pamoate rapidly suppresses gonadotropin release without the initial flare effect seen with GnRH agonists. This leads to suppression of sex hormone production (testosterone and estrogen), making it useful in hormone-dependent conditions. The pamoate salt formulation provides extended-release characteristics for sustained therapeutic effect.
Approved indications
- Prostate cancer (hormone-dependent)
- Ovarian suppression in assisted reproductive technology
Common side effects
- Hot flashes
- Injection site reactions
- Fatigue
- Decreased libido
- Erectile dysfunction
Key clinical trials
- PPOS vs GnRH Antagonist in Ovarian Stimulation (ProGanOS Study) (NA)
- A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA) (PHASE3)
- Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Women With PCOS Undergoing PGT-A (PHASE3)
- Trial Comparing Subcutaneous Natural Progesterone (Prolutex) vs. Cetrorelix Acetate for Luteinizing Hormone Surge Suppression in Freeze-All IVF Cycles. (PHASE4)
- NATural Ovarian Stimulation (PHASE4)
- Effectiveness of Generic Versus Reference Cetrorelix Acetate for Ovarian Stimulation Using a Gonadotropin-releasing Hormone（GnRH）Antagonist Protocol in Women Undergoing IVF (NA)
- Comparison of the Live Birth Rate Between the PPOS and the GnRH Antagonist Protocol in Patients Undergoing IVF (NA)
- Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Patients Undergoing PGT-A (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |