Last reviewed · How we verify
cetrorelix (cetrotide)
cetrorelix (cetrotide) is a GnRH antagonist Small molecule drug developed by Eugonia. It is currently FDA-approved for Prevention of premature luteinizing hormone surge in women undergoing controlled ovarian hyperstimulation for assisted reproductive technology (in vitro fertilization). Also known as: GnRH antagonist, Cetrorelix, Cetrotide, Serono.
Cetrorelix is a gonadotropin-releasing hormone (GnRH) antagonist that blocks GnRH receptors to suppress luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion.
Cetrorelix, also known as cetrotide, is a protein modality used as a GnRH antagonist. It is studied in various clinical trials for conditions such as infertility, polycystic ovary syndrome, and IVF.
At a glance
| Generic name | cetrorelix (cetrotide) |
|---|---|
| Also known as | GnRH antagonist, Cetrorelix, Cetrotide, Serono |
| Sponsor | Eugonia |
| Drug class | GnRH antagonist |
| Target | GnRH receptor |
| Modality | Small molecule |
| Therapeutic area | Reproductive/Fertility |
| Phase | FDA-approved |
Mechanism of action
By competitively antagonizing GnRH receptors in the pituitary gland, cetrorelix rapidly suppresses gonadotropin release without the initial flare effect seen with GnRH agonists. This leads to controlled suppression of ovarian steroid production, making it useful for preventing premature LH surge during controlled ovarian hyperstimulation in assisted reproductive technology.
Approved indications
- Prevention of premature luteinizing hormone surge in women undergoing controlled ovarian hyperstimulation for assisted reproductive technology (in vitro fertilization)
Common side effects
- Ovarian hyperstimulation syndrome
- Headache
- Injection site reactions
- Nausea
- Abdominal pain
Key clinical trials
- PPOS vs GnRH Antagonist in Ovarian Stimulation (ProGanOS Study) (NA)
- A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA) (PHASE3)
- Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Women With PCOS Undergoing PGT-A (PHASE3)
- Trial Comparing Subcutaneous Natural Progesterone (Prolutex) vs. Cetrorelix Acetate for Luteinizing Hormone Surge Suppression in Freeze-All IVF Cycles. (PHASE4)
- NATural Ovarian Stimulation (PHASE4)
- Effectiveness of Generic Versus Reference Cetrorelix Acetate for Ovarian Stimulation Using a Gonadotropin-releasing Hormone（GnRH）Antagonist Protocol in Women Undergoing IVF (NA)
- Comparison of the Live Birth Rate Between the PPOS and the GnRH Antagonist Protocol in Patients Undergoing IVF (NA)
- Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Patients Undergoing PGT-A (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- cetrorelix (cetrotide) CI brief — competitive landscape report
- cetrorelix (cetrotide) updates RSS · CI watch RSS
- Eugonia portfolio CI
Frequently asked questions about cetrorelix (cetrotide)
What is cetrorelix (cetrotide)?
How does cetrorelix (cetrotide) work?
What is cetrorelix (cetrotide) used for?
Who makes cetrorelix (cetrotide)?
Is cetrorelix (cetrotide) also known as anything else?
What drug class is cetrorelix (cetrotide) in?
What development phase is cetrorelix (cetrotide) in?
What are the side effects of cetrorelix (cetrotide)?
What does cetrorelix (cetrotide) target?
Related
- Drug class: All GnRH antagonist drugs
- Target: All drugs targeting GnRH receptor
- Manufacturer: Eugonia — full pipeline
- Therapeutic area: All drugs in Reproductive/Fertility
- Indication: Drugs for Prevention of premature luteinizing hormone surge in women undergoing controlled ovarian hyperstimulation for assisted reproductive technology (in vitro fertilization)
- Also known as: GnRH antagonist, Cetrorelix, Cetrotide, Serono
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing