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Antagonist GnRH Cetrotide

Instituto Valenciano de Infertilidad, IVI VALENCIA · FDA-approved active Small molecule

Antagonist GnRH Cetrotide is a GnRH antagonist Small molecule drug developed by Instituto Valenciano de Infertilidad, IVI VALENCIA. It is currently FDA-approved for Prevention of premature luteinizing hormone surge in women undergoing controlled ovarian hyperstimulation for assisted reproductive technology (in vitro fertilization).

Cetrotide is a GnRH antagonist that directly blocks gonadotropin-releasing hormone receptors to suppress luteinizing hormone and follicle-stimulating hormone secretion.

Cetrotide is a GnRH antagonist that directly blocks gonadotropin-releasing hormone receptors to suppress luteinizing hormone and follicle-stimulating hormone secretion. Used for Prevention of premature luteinizing hormone surge in women undergoing controlled ovarian hyperstimulation for assisted reproductive technology (in vitro fertilization).

At a glance

Generic nameAntagonist GnRH Cetrotide
SponsorInstituto Valenciano de Infertilidad, IVI VALENCIA
Drug classGnRH antagonist
TargetGnRH receptor
ModalitySmall molecule
Therapeutic areaReproductive Medicine / Fertility
PhaseFDA-approved

Mechanism of action

By competitively antagonizing GnRH receptors in the pituitary gland, cetrotide rapidly suppresses the release of LH and FSH without an initial flare effect. This prevents premature ovulation during controlled ovarian hyperstimulation in assisted reproductive technology cycles, allowing precise timing of oocyte retrieval.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Antagonist GnRH Cetrotide

What is Antagonist GnRH Cetrotide?

Antagonist GnRH Cetrotide is a GnRH antagonist drug developed by Instituto Valenciano de Infertilidad, IVI VALENCIA, indicated for Prevention of premature luteinizing hormone surge in women undergoing controlled ovarian hyperstimulation for assisted reproductive technology (in vitro fertilization).

How does Antagonist GnRH Cetrotide work?

Cetrotide is a GnRH antagonist that directly blocks gonadotropin-releasing hormone receptors to suppress luteinizing hormone and follicle-stimulating hormone secretion.

What is Antagonist GnRH Cetrotide used for?

Antagonist GnRH Cetrotide is indicated for Prevention of premature luteinizing hormone surge in women undergoing controlled ovarian hyperstimulation for assisted reproductive technology (in vitro fertilization).

Who makes Antagonist GnRH Cetrotide?

Antagonist GnRH Cetrotide is developed and marketed by Instituto Valenciano de Infertilidad, IVI VALENCIA (see full Instituto Valenciano de Infertilidad, IVI VALENCIA pipeline at /company/instituto-valenciano-de-infertilidad-ivi-valencia).

What drug class is Antagonist GnRH Cetrotide in?

Antagonist GnRH Cetrotide belongs to the GnRH antagonist class. See all GnRH antagonist drugs at /class/gnrh-antagonist.

What development phase is Antagonist GnRH Cetrotide in?

Antagonist GnRH Cetrotide is FDA-approved (marketed).

What are the side effects of Antagonist GnRH Cetrotide?

Common side effects of Antagonist GnRH Cetrotide include Headache, Ovarian hyperstimulation syndrome (OHSS), Abdominal pain/discomfort, Nausea, Injection site reactions.

What does Antagonist GnRH Cetrotide target?

Antagonist GnRH Cetrotide targets GnRH receptor and is a GnRH antagonist.

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