Clobetasol propionate cream · Dermatology Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.
Daivonex® scalp solution · Dermatology Daivonex scalp solution is a vitamin D3 analogue that binds to vitamin D receptors on skin cells to reduce excessive cell proliferation and inflammation characteristic of psoriasis.
Diclofenac sodium gel 3% · Pain management / Rheumatology Diclofenac sodium inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain at the site of topical application.
Doxycycline (Oracea) · Dermatology Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, and at sub-antimicrobial doses in Oracea formulation, it reduces matrix metalloproteinase activity to decrease inflammation.
innohep® · Cardiovascular Innohep is a low-molecular-weight heparin that inhibits blood coagulation by enhancing the activity of antithrombin III against factor Xa and thrombin.
Metronidazole (Metrogel) · Dermatology; Infectious Disease Metronidazole is a nitroimidazole antibiotic that disrupts bacterial and parasitic DNA by generating reactive oxygen species, leading to cell death.
Petrolatum ointment · Dermatology Petrolatum ointment forms an occlusive barrier on the skin surface to prevent water loss and protect against irritants.
Topical suspension vehicle · Dermatology A topical suspension vehicle is a pharmaceutical formulation designed to deliver active ingredients to the skin surface through a liquid suspension base.
Xamiol® Gel · Dermatology Xamiol® Gel combines calcipotriene (a vitamin D analog) and betamethasone dipropionate (a corticosteroid) to reduce skin inflammation and normalize keratinocyte differentiation in psoriasis.
Phase 3 pipeline
Aerosol foam vehicle · Dermatology An aerosol foam vehicle formulation designed to deliver active pharmaceutical ingredients topically to affected skin areas with improved coverage and adherence.
Betamethasone-17,21-dipropionate · Dermatology Betamethasone dipropionate is a potent topical corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors.
Calcipotriene/betamethasone gel and ointment · Dermatology Calcipotriene (a vitamin D analog) reduces skin cell proliferation and promotes differentiation, while betamethasone (a corticosteroid) suppresses inflammation and immune response in psoriatic skin.
Calcipotriol BDP gel · Dermatology Calcipotriol is a vitamin D3 analog that binds to the vitamin D receptor to regulate skin cell differentiation and reduce inflammation in psoriasis.
Calcipotriol plus betamethasone · Dermatology Calcipotriol (a vitamin D analogue) and betamethasone (a corticosteroid) work together to reduce skin inflammation and normalize keratinocyte differentiation in psoriasis.
Calcipotriol plus hydrocortisone ointment · Dermatology Calcipotriol (a vitamin D analogue) reduces skin cell proliferation and promotes differentiation, while hydrocortisone (a corticosteroid) suppresses inflammation and immune responses in the skin.
Calcipotriol plus hydrocortisone ointment vehicle · Dermatology Calcipotriol (a vitamin D analogue) reduces keratinocyte proliferation and promotes differentiation, while hydrocortisone provides anti-inflammatory effects to treat psoriasis.
Calcipotriol scalp solution · Dermatology Calcipotriol is a vitamin D3 analog that binds to the vitamin D receptor to regulate skin cell proliferation and differentiation, reducing psoriatic plaques.
Daivobet® gel · Dermatology Daivobet combines calcipotriene (a vitamin D analog) and betamethasone dipropionate (a corticosteroid) to reduce inflammation and normalize skin cell differentiation in psoriasis.
Delgocitinib cream · Dermatology / Immunology Delgocitinib is a JAK inhibitor that suppresses inflammatory cytokine signaling in immune cells to reduce skin inflammation and itching in atopic dermatitis.
Dovobet® ointment · Dermatology Dovobet combines calcipotriene (a vitamin D analogue) and betamethasone dipropionate (a corticosteroid) to reduce skin inflammation and normalize keratinocyte differentiation in psoriasis.
Dovonex® = calcipotriol · Dermatology Calcipotriol is a vitamin D3 analog that binds to the vitamin D receptor to regulate skin cell proliferation and differentiation, reducing excessive keratinocyte growth.
Ingenol mebutate gel 0.05 % · Dermatology Ingenol mebutate activates protein kinase C (PKC) to induce rapid necrosis of actinic keratosis cells and promote immune-mediated clearance of damaged skin.
Ingenol metabute · Dermatology Ingenol mebutate is a protein kinase C (PKC) activator that induces rapid necrosis of actinic keratosis cells and promotes immune-mediated clearance of treated lesions.
LEO 43204 gel · Dermatology LEO 43204 is a topical calcineurin inhibitor that suppresses local immune responses in the skin.
LEO 80185 gel · Dermatology LEO 80185 is a topical calcineurin inhibitor that suppresses local immune responses in the skin.
LEO 80185 vehicle · Dermatology LEO 80185 vehicle is a topical formulation designed to deliver active pharmaceutical ingredients to the skin.
LEO 80190 · Dermatology LEO 80190 is a topical phosphodiesterase 4 (PD4) inhibitor that reduces inflammatory cytokine production in skin.
LEO 80190 Vehicle · Dermatology LEO 80190 Vehicle is a topical formulation vehicle designed to enhance dermal delivery of active pharmaceutical ingredients.
LEO 90100 · Dermatology LEO 90100 is a topical phosphodiesterase 4 (PD4) inhibitor that reduces inflammatory cytokine production in skin.
LEO 90100 aerosol foam · Dermatology LEO 90100 is a topical corticosteroid aerosol foam formulation designed for enhanced skin penetration and coverage in inflammatory skin conditions.
LEO 90100 aerosol foam vehicle · Dermatology LEO 90100 is a topical aerosol foam vehicle designed to deliver active pharmaceutical ingredients to the skin with improved penetration and patient convenience.
LEO 90100 foam · Dermatology LEO 90100 foam is a topical corticosteroid formulation designed for enhanced skin penetration and anti-inflammatory effects in dermatological conditions.
LEO 90105 = calcipotriol + betamethasone dipropionate · Dermatology LEO 90105 combines a vitamin D analog (calcipotriol) that regulates skin cell differentiation with a potent topical corticosteroid (betamethasone dipropionate) to reduce inflammation and abnormal keratinocyte proliferation in psoriasis.
LEO43204 gel · Dermatology LEO43204 is a topical retinoid that modulates retinoid receptor signaling to reduce inflammation and promote skin cell differentiation in dermatological conditions.
Placebo + TCS · Dermatology This is a control arm combining placebo with topical corticosteroid (TCS) therapy, used as a comparator in clinical trials to establish efficacy of an investigational treatment.
Rinderon® - DP = betamethasone dipropionate · Dermatology Rinderon inhibits the body's inflammatory response by suppressing the production of various pro-inflammatory cytokines.
Tacalcitol ointment · Dermatology Tacalcitol ointment is a synthetic vitamin D3 analog that modulates the vitamin D receptor.
Tralokinumab + TCS · Dermatology Tralokinumab is an IL-13 inhibitor, and when combined with topical corticosteroids (TCS), it targets the underlying inflammatory pathways in atopic dermatitis.
Vehicle gel (SH H 655 PBA) · Dermatology Vehicle gel is a topical formulation used to deliver active pharmaceutical ingredients to the skin.
Betamethasone dipropionate aerosol spray · Dermatology Betamethasone dipropionate aerosol spray is a topical corticosteroid that reduces inflammation and suppresses the immune system.
Betamethasone dipropionate cream · Dermatology Betamethasone dipropionate cream is a topical corticosteroid that reduces inflammation and itching by suppressing the immune system.
Betamethasone plus calcipotriol · Dermatology Betamethasone is a glucocorticoid receptor agonist, while calcipotriol is a vitamin D3 analog that acts as a retinoid X receptor agonist.
Betnovat® ointment · Dermatology Betnovat ointment is a topical corticosteroid that reduces inflammation and itching by suppressing the immune system.
Brimonidine Tartrate Gel · Dermatology Brimonidine tartrate gel works by reducing the amount of norepinephrine in the body, which helps to decrease redness and swelling in the skin.
Calcipotriene plus betamethasone dipropionate ointment · Dermatology Calcipotriene plus betamethasone dipropionate ointment works by reducing inflammation and slowing the growth of skin cells in the treatment of psoriasis.