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Clobetasol propionate cream

LEO Pharma · FDA-approved active Small molecule

Clobetasol propionate cream is a Topical corticosteroid (Class I, super-potent) Small molecule drug developed by LEO Pharma. It is currently FDA-approved for Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, Psoriasis, Lichen planus. Also known as: Dermovate, Clobex® Spray.

Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.

Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors. Used for Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, Psoriasis, Lichen planus.

At a glance

Generic nameClobetasol propionate cream
Also known asDermovate, Clobex® Spray
SponsorLEO Pharma
Drug classTopical corticosteroid (Class I, super-potent)
TargetGlucocorticoid receptor
ModalitySmall molecule
Therapeutic areaDermatology
PhaseFDA-approved

Mechanism of action

Clobetasol propionate is a Class I (super-potent) corticosteroid that works by activating intracellular glucocorticoid receptors, leading to decreased production of inflammatory mediators, reduced immune cell infiltration, and suppression of local inflammatory responses. This results in rapid reduction of erythema, pruritus, and other signs of skin inflammation in dermatological conditions.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Clobetasol propionate cream

What is Clobetasol propionate cream?

Clobetasol propionate cream is a Topical corticosteroid (Class I, super-potent) drug developed by LEO Pharma, indicated for Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, Psoriasis, Lichen planus.

How does Clobetasol propionate cream work?

Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.

What is Clobetasol propionate cream used for?

Clobetasol propionate cream is indicated for Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, Psoriasis, Lichen planus, Eczema, Dermatitis.

Who makes Clobetasol propionate cream?

Clobetasol propionate cream is developed and marketed by LEO Pharma (see full LEO Pharma pipeline at /company/leo-pharma).

Is Clobetasol propionate cream also known as anything else?

Clobetasol propionate cream is also known as Dermovate, Clobex® Spray.

What drug class is Clobetasol propionate cream in?

Clobetasol propionate cream belongs to the Topical corticosteroid (Class I, super-potent) class. See all Topical corticosteroid (Class I, super-potent) drugs at /class/topical-corticosteroid-class-i-super-potent.

What development phase is Clobetasol propionate cream in?

Clobetasol propionate cream is FDA-approved (marketed).

What are the side effects of Clobetasol propionate cream?

Common side effects of Clobetasol propionate cream include Skin atrophy, Striae, Telangiectasia, Folliculitis, Hypertrichosis, Acneiform eruptions.

What does Clobetasol propionate cream target?

Clobetasol propionate cream targets Glucocorticoid receptor and is a Topical corticosteroid (Class I, super-potent).

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