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Betamethasone-17,21-dipropionate

LEO Pharma · Phase 3 active Small molecule

Betamethasone dipropionate is a potent topical corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors.

Betamethasone dipropionate is a potent topical corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors. Used for Inflammatory and pruritic dermatoses responsive to topical corticosteroids, Eczema, psoriasis, and other chronic inflammatory skin conditions.

At a glance

Generic nameBetamethasone-17,21-dipropionate
SponsorLEO Pharma
Drug classTopical corticosteroid
TargetGlucocorticoid receptor
ModalitySmall molecule
Therapeutic areaDermatology
PhasePhase 3

Mechanism of action

This synthetic corticosteroid works by penetrating skin tissue and binding to intracellular glucocorticoid receptors, which translocate to the nucleus and modulate gene expression. This leads to decreased production of inflammatory mediators, reduced immune cell infiltration, and suppression of local inflammatory responses. The dipropionate ester formulation enhances skin penetration and potency compared to the parent betamethasone molecule.

Approved indications

Common side effects

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