Last reviewed · How we verify
Daivonex® scalp solution
Daivonex scalp solution is a vitamin D3 analogue that binds to vitamin D receptors on skin cells to reduce excessive cell proliferation and inflammation characteristic of psoriasis.
Daivonex scalp solution is a vitamin D3 analogue that binds to vitamin D receptors on skin cells to reduce excessive cell proliferation and inflammation characteristic of psoriasis. Used for Psoriasis of the scalp.
At a glance
| Generic name | Daivonex® scalp solution |
|---|---|
| Sponsor | LEO Pharma |
| Drug class | Vitamin D3 analogue |
| Target | Vitamin D receptor (VDR) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Calcipotriol (the active ingredient) is a synthetic analogue of calcitriol (active vitamin D3) that modulates keratinocyte differentiation and proliferation by activating vitamin D receptors. This leads to normalization of the abnormal skin cell growth cycle seen in psoriasis and reduces inflammatory cytokine production, thereby improving scaling, erythema, and plaque formation on the scalp.
Approved indications
- Psoriasis of the scalp
Common side effects
- Irritation at application site
- Burning or stinging sensation
- Hypercalcemia (with excessive use)
Key clinical trials
- Efficacy and Safety of Xamiol® Gel Compared to Calcipotriol Scalp Solution in Patients With Scalp Psoriasis (PHASE3)
- Long-term Treatment of Scalp Psoriasis With Xamiol® Gel in a Large Adult Chinese Population (PHASE4)
- Comparison of Indigo Naturalis Oil Extract and Calcipotriol Solution in Treating Psoriasis (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |