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Calcipotriol plus betamethasone
Calcipotriol plus betamethasone is a Vitamin D analogue plus corticosteroid combination Small molecule drug developed by LEO Pharma. It is currently in Phase 3 development for Plaque psoriasis, Psoriasis vulgaris.
Calcipotriol (a vitamin D analogue) and betamethasone (a corticosteroid) work together to reduce skin inflammation and normalize keratinocyte differentiation in psoriasis.
Calcipotriol (a vitamin D analogue) and betamethasone (a corticosteroid) work together to reduce skin inflammation and normalize keratinocyte differentiation in psoriasis. Used for Plaque psoriasis, Psoriasis vulgaris.
At a glance
| Generic name | Calcipotriol plus betamethasone |
|---|---|
| Sponsor | LEO Pharma |
| Drug class | Vitamin D analogue plus corticosteroid combination |
| Target | Vitamin D receptor (VDR) and glucocorticoid receptor (GR) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Calcipotriol activates vitamin D receptors to promote differentiation and reduce proliferation of skin cells, while betamethasone provides potent anti-inflammatory effects through glucocorticoid receptor activation. The combination addresses both the underlying pathophysiology and acute inflammation of psoriatic plaques, with synergistic efficacy superior to either agent alone.
Approved indications
- Plaque psoriasis
- Psoriasis vulgaris
Common side effects
- Skin irritation or burning at application site
- Hypercalcemia (with excessive use)
- Local skin atrophy (from corticosteroid component)
- Folliculitis
Key clinical trials
- A Phase III Trial To Evaluate The Efficacy And Safety Of MC2-01 Cream Compared To CAL/BDP Gel and Vehicle In Plaque Psoriasis Subjects (PHASE3)
- Residual Disease MEMory in PSOriasis Skin During EnstiLAR® and Narrow-band Ultraviolet B Therapy: The MEMPSOLAR Study (PHASE4)
- Efficacy and Safety of Xamiol® Gel Compared to Calcipotriol Scalp Solution in Patients With Scalp Psoriasis (PHASE3)
- A Psoriasis Plaque Test With LEO 29102 Cream and Its Combination Products (PHASE2)
- LEO 90105 Ointment in Japanese Subjects With Psoriasis (PHASE3)
- Safety and Efficacy of TACLONEX Ointment in Adolescent Patients (Aged 12 to 17 Years) With Psoriasis Vulgaris (PHASE2)
- The Pharmacokinetics of LEO 90105 (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Japanese Subjects With Extensive Psoriasis Vulgaris (PHASE1, PHASE2)
- Safety and Efficacy of LEO 80185 Gel in Adolescent Subjects (Aged 12 to 17) With Scalp Psoriasis (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Calcipotriol plus betamethasone CI brief — competitive landscape report
- Calcipotriol plus betamethasone updates RSS · CI watch RSS
- LEO Pharma portfolio CI
Frequently asked questions about Calcipotriol plus betamethasone
What is Calcipotriol plus betamethasone?
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Who makes Calcipotriol plus betamethasone?
What drug class is Calcipotriol plus betamethasone in?
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What are the side effects of Calcipotriol plus betamethasone?
What does Calcipotriol plus betamethasone target?
Related
- Drug class: All Vitamin D analogue plus corticosteroid combination drugs
- Target: All drugs targeting Vitamin D receptor (VDR) and glucocorticoid receptor (GR)
- Manufacturer: LEO Pharma — full pipeline
- Therapeutic area: All drugs in Dermatology
- Indication: Drugs for Plaque psoriasis
- Indication: Drugs for Psoriasis vulgaris
- Compare: Calcipotriol plus betamethasone vs similar drugs
- Pricing: Calcipotriol plus betamethasone cost, discount & access