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Calcipotriol BDP gel
Calcipotriol is a vitamin D3 analog that binds to the vitamin D receptor to regulate skin cell differentiation and reduce inflammation in psoriasis.
Calcipotriol is a vitamin D3 analog that binds to the vitamin D receptor to regulate skin cell differentiation and reduce inflammation in psoriasis. Used for Plaque psoriasis (topical treatment).
At a glance
| Generic name | Calcipotriol BDP gel |
|---|---|
| Sponsor | LEO Pharma |
| Drug class | Vitamin D3 analog / Corticosteroid combination |
| Target | Vitamin D receptor (VDR); Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Calcipotriol activates the vitamin D receptor on keratinocytes and immune cells, promoting normal differentiation of skin cells and suppressing the inflammatory T-cell response characteristic of psoriasis. BDP (betamethasone dipropionate) is a potent corticosteroid that provides additional anti-inflammatory effects. The combination gel formulation delivers both agents topically to affected skin.
Approved indications
- Plaque psoriasis (topical treatment)
Common side effects
- Skin irritation or burning at application site
- Hypercalcemia (with systemic absorption)
- Local skin atrophy (corticosteroid-related)
Key clinical trials
- A Phase III Trial To Evaluate The Efficacy And Safety Of MC2-01 Cream Compared To CAL/BDP Gel and Vehicle In Plaque Psoriasis Subjects (PHASE3)
- LEO 90100 Aerosol Foam Compared to Calcipotriol Plus Betamethasone Dipropionate Gel in Subjects With Psoriasis Vulgaris (PHASE3)
- An Exploratory Psoriasis Plaque Test Study With Different Dose Combinations of Calcipotriol Plus Betamethasone Dipropionate in the Daivobet® Gel Vehicle in Psoriasis Vulgaris (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Calcipotriol BDP gel CI brief — competitive landscape report
- Calcipotriol BDP gel updates RSS · CI watch RSS
- LEO Pharma portfolio CI