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Calcipotriol scalp solution
Calcipotriol is a vitamin D3 analog that binds to the vitamin D receptor to regulate skin cell proliferation and differentiation, reducing psoriatic plaques.
Calcipotriol is a vitamin D3 analog that binds to the vitamin D receptor to regulate skin cell proliferation and differentiation, reducing psoriatic plaques. Used for Psoriasis of the scalp.
At a glance
| Generic name | Calcipotriol scalp solution |
|---|---|
| Sponsor | LEO Pharma |
| Drug class | Vitamin D3 analog |
| Target | Vitamin D receptor (VDR) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Calcipotriol activates the vitamin D receptor on keratinocytes and immune cells, promoting terminal differentiation of skin cells and suppressing the excessive proliferation characteristic of psoriasis. This leads to normalization of the epidermal cell cycle and reduction of inflammatory cytokine production in psoriatic lesions.
Approved indications
- Psoriasis of the scalp
Common side effects
- Irritation at application site
- Burning sensation
- Pruritus
- Erythema
Key clinical trials
- Efficacy and Safety of Xamiol® Gel Compared to Calcipotriol Scalp Solution in Patients With Scalp Psoriasis (PHASE3)
- Long-term Treatment of Scalp Psoriasis With Xamiol® Gel in a Large Adult Chinese Population (PHASE4)
- Efficacy of Calcipotriol Plus Betamethasone Gel Versus Calcipotriol Scalp Solution in Scalp Psoriasis (PHASE3)
- Comparison of Indigo Naturalis Oil Extract and Calcipotriol Solution in Treating Psoriasis (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |