{"id":"calcipotriol-scalp-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Irritation at application site"},{"rate":null,"effect":"Burning sensation"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"}]},"_chembl":{"chemblId":"CHEMBL4563773","moleculeType":"Unknown","molecularWeight":"412.61"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Calcipotriol activates the vitamin D receptor on keratinocytes and immune cells, promoting terminal differentiation of skin cells and suppressing the excessive proliferation characteristic of psoriasis. This leads to normalization of the epidermal cell cycle and reduction of inflammatory cytokine production in psoriatic lesions.","oneSentence":"Calcipotriol is a vitamin D3 analog that binds to the vitamin D receptor to regulate skin cell proliferation and differentiation, reducing psoriatic plaques.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:04:38.369Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Psoriasis of the scalp"}]},"trialDetails":[{"nctId":"NCT01195831","phase":"PHASE3","title":"Efficacy and Safety of Xamiol® Gel Compared to Calcipotriol Scalp Solution in Patients With Scalp Psoriasis","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2010-09","conditions":"Scalp Psoriasis","enrollment":244},{"nctId":"NCT02533973","phase":"PHASE4","title":"Long-term Treatment of Scalp Psoriasis With Xamiol® Gel in a Large Adult Chinese Population","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2015-09","conditions":"Psoriasis Vulgaris","enrollment":951},{"nctId":"NCT00243464","phase":"PHASE3","title":"Efficacy of Calcipotriol Plus Betamethasone Gel Versus Calcipotriol Scalp Solution in Scalp Psoriasis","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2005-09","conditions":"Psoriasis of Scalp","enrollment":300},{"nctId":"NCT01445886","phase":"PHASE2, PHASE3","title":"Comparison of Indigo Naturalis Oil Extract and Calcipotriol Solution in Treating Psoriasis","status":"COMPLETED","sponsor":"Yin-ku Lin","startDate":"2011-01","conditions":"Nail Psoriasis","enrollment":33}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Calcipotriol scalp solution","genericName":"Calcipotriol scalp solution","companyName":"LEO Pharma","companyId":"leo-pharma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calcipotriol is a vitamin D3 analog that binds to the vitamin D receptor to regulate skin cell proliferation and differentiation, reducing psoriatic plaques. Used for Psoriasis of the scalp.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}