Selective Serotonin Reuptake Inhibitor (SSRI)
This page covers all Selective Serotonin Reuptake Inhibitor (SSRI) drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Serotonin reuptake transporter, Cytochrome P450 2C19, Melanocortin receptor 5, 5-hydroxytryptamine receptor 2A, Serotonin transporter (SERT).
Targets
Serotonin reuptake transporter · Cytochrome P450 2C19, Melanocortin receptor 5, 5-hydroxytryptamine receptor 2A · Serotonin transporter (SERT) · Dopamine D2 receptor (partial agonist), serotonin 5-HT1A receptor (partial agonist), serotonin transporter (SERT inhibitor) · Serotonin (5-HT) reuptake transporter · Serotonin transporter · Serotonin Transporter (SERT) · serotonin transporter · 5-hydroxytryptamine receptor 1A, D(2) dopamine receptor, Histamine H1 receptor
Marketed (38)
- Prozac · Eli Lilly and Company · Neuroscience · 1000.0
Fluoxetine inhibits CNS neuronal uptake of serotonin, though exact mechanism unknown. - Zoloft · Pfizer Inc. · Neuroscience · 350
Selective serotonin reuptake inhibitor (SSRI) that blocks the serotonin transporter, increasing synaptic serotonin to improve mood and reduce anxiety. - Placebo & Citalopram · University of Colorado, Denver · Psychiatry / Mental Health
Citalopram is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin availability in the brain by blocking its reuptake at the presynaptic neuron. - escitalopram and sertraline · Oregon Health and Science University · Psychiatry / Mental Health
Both escitalopram and sertraline are selective serotonin reuptake inhibitors (SSRIs) that increase serotonin availability in the brain by blocking its reabsorption at the synaptic cleft. - Citalopram HCl · Universitaire Ziekenhuizen KU Leuven · Psychiatry / Mental Health
Citalopram selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Selective serotonin reuptake inhibitors · Faculdade de Medicina do ABC · Psychiatry / Neurology
SSRIs block the reuptake of serotonin at the presynaptic neuron, increasing serotonin concentration in the synaptic cleft. - oral escitalopram · NYU Langone Health · Psychiatry / Mental Health
Escitalopram selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Zoloft tablets · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. · Psychiatry / Neurology
Zoloft selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Continued Paroxetine CR · Massachusetts General Hospital · Psychiatry / Mental Health
Paroxetine CR is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin availability in the brain by blocking its reuptake at the synaptic cleft. - Luvox CR · Rogers Center for Research & Training, Inc. · Psychiatry / Mental Health
Luvox CR is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin availability in the brain by blocking its reuptake at the presynaptic neuron. - citalopram (SSRI) · Fundació Sant Joan de Déu · Psychiatry / Mental Health
Citalopram selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Open Label (OL) Paroxetine · VA Office of Research and Development · Psychiatry / Neurology
Paroxetine selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Escitalopram (Lexapro) · University of Rochester · Psychiatry / Neurology
Escitalopram selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Zoloft (antidepressant) · Unity Health Toronto · Psychiatry / Neurology
Zoloft selectively blocks the reuptake of serotonin in the brain, increasing serotonin availability at synapses. - placebo + fluoxetine · University of Florida · Psychiatry / Mental Health
Fluoxetine selectively inhibits serotonin reuptake in the brain, increasing serotonin availability at synapses to improve mood and reduce depressive symptoms. - Aripiprazole/Escitalopram combination · Massachusetts General Hospital · Psychiatry
This combination uses aripiprazole (a dopamine D2 receptor partial agonist) and escitalopram (a selective serotonin reuptake inhibitor) to modulate both dopaminergic and serotonergic neurotransmission for psychiatric symptom management. - Sertraline HCl · Tri-Service General Hospital · Psychiatry / Neurology
Sertraline selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Selective serotonin re-uptake inhibitor · New Valley University · Psychiatry / Neurology
SSRIs block the reuptake of serotonin at the presynaptic neuron, increasing serotonin concentration in the synaptic cleft. - Paxil-CR · University of Oklahoma · Psychiatry / Neurology
Paxil-CR is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin availability in the brain by blocking its reuptake at the synaptic cleft. - Fluvoxamine+sugar pill · Guangdong Provincial People's Hospital · Psychiatry / Neurology
Fluvoxamine selectively inhibits serotonin reuptake at the presynaptic neuron, increasing synaptic serotonin availability. - Fluoxetine (prozac) · Neuropharm · Psychiatry / Neurology
Fluoxetine selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Lexapro · Generic (originally Lundbeck/Forest) · Neuroscience
Inhibits CNS neuronal reuptake of serotonin (5-HT), potentiating serotonergic activity. - Paroxetine · Pfizer Inc. · Neuroscience
Inhibits neuronal reuptake of serotonin in the central nervous system, presumed mechanism for treating psychiatric disorders. - SSRI antidepressants · Nanjing Medical University · Psychiatry / Neurology
SSRIs block the reuptake of serotonin at the presynaptic neuron, increasing serotonin availability in the synaptic cleft. - Cipralex (escitalopram) · Medical University of Vienna · Psychiatry / Mental Health
Cipralex selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - SSRI (SEROPLEX ou ZOLOFT) · Centre Hospitalier Universitaire Dijon · Psychiatry / Neurology
SSRIs block the reuptake of serotonin in the brain, increasing serotonin availability in synapses to improve mood and reduce anxiety. - Paroxetine CR · Otsuka Pharmaceutical Development & Commercialization, Inc. · Psychiatry / Neurology
Paroxetine CR selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Track B · ATS Clinical Research · Psychiatry
Track B is a medication that works by inhibiting the reuptake of certain neurotransmitters. - Paroxetine + relaxation · University of Göttingen · Psychiatry / Mental Health
Paroxetine inhibits serotonin reuptake to elevate mood and reduce anxiety, while relaxation techniques provide behavioral reinforcement of anxiolytic effects. - MDD diagnosis and Fluoxetine treatment · University of Pennsylvania · Neuroscience
- Placebo and SSRI · All India Institute of Medical Sciences, Bhubaneswar · Psychiatry / Mental Health
SSRIs increase synaptic serotonin by inhibiting its reuptake, while placebo provides a control comparator with no active pharmacological mechanism. - Sertraline [Zoloft] · Johns Hopkins University · Psychiatry / Neurology
Sertraline selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - citalopram (celexa) · Sunnybrook Health Sciences Centre · Psychiatry / Mental Health
Citalopram selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Lexapro (escitalopram) · St. Luke's-Roosevelt Hospital Center · Psychiatry / Mental Health
Escitalopram selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Low severity group: Escitalopram · University of Texas Southwestern Medical Center · Psychiatry / Neurology
Escitalopram selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - High severity group: Escitalopram · University of Texas Southwestern Medical Center · Psychiatry / Neurology
Escitalopram selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Track A · ATS Clinical Research · Psychiatry
Track A is a medication that works by inhibiting the reuptake of certain neurotransmitters. - sertraline fluvoxamine · Second Affiliated Hospital, School of Medicine, Zhejiang University · Psychiatry / Mental Health
This is a combination of two selective serotonin reuptake inhibitors (SSRIs) that increase synaptic serotonin by blocking its reuptake at the presynaptic membrane.
Phase 3 pipeline (12)
- Sertraline (SRT) · Johns Hopkins University · Psychiatry / Neurology
Sertraline selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Paroxetine IR · GlaxoSmithKline · Psychiatry/Neurology
Paroxetine selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - antidepressant medications, flexible drug choice · Sir Mortimer B. Davis - Jewish General Hospital · Psychiatry
This antidepressant medication works by increasing the levels of certain neurotransmitters in the brain. - Dapoxetine hydrochloride · Janssen Research & Development, LLC · Urology / Sexual Health
Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels in the central nervous system to delay ejaculation. - Comparator: paroxetine HCL · Merck Sharp & Dohme LLC · Psychiatry / Neurology
Paroxetine HCl selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Continuation phase fluoxetine · University of Texas Southwestern Medical Center · Psychiatry / Mental Health
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin availability in the brain by blocking its reuptake at the presynaptic neuron. - Anyu Peibo · Shanghai Mental Health Center · Psychiatry
Anyu Peibo is a medication used to treat depression. - D07001-Softgel Capsules · InnoPharmax Inc. · Psychiatry
D07001-Softgel Capsules is a medication that works by inhibiting the reuptake of a specific neurotransmitter. - SPM 929 · UCB Pharma · Psychiatry
SPM 929 is a selective serotonin reuptake inhibitor (SSRI) that works by increasing the levels of serotonin in the brain. - Noex · Eurofarma Laboratorios S.A. · Psychiatry
Noex is a medication that works by inhibiting the enzyme responsible for the breakdown of a certain neurotransmitter. - paroxetine hydrochloride hydrate · GlaxoSmithKline · Psychiatry / Neurology
Paroxetine selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. - Escitalopram oxylate · AstraZeneca · Psychiatry / Neurology
Escitalopram oxalate selectively inhibits the reuptake of serotonin at the neuronal membrane, increasing serotonin availability in the synaptic cleft.
Phase 2 pipeline (7)
- Citalopram i.v. and p.o · Istituto Auxologico Italiano · Neurology
Selective serotonin reuptake inhibitor - Aggripal® · Novartis · Neurology
Selective serotonin reuptake inhibitor - Innovator Escitalopram · Shanghai Mental Health Center · Neurology
Selective serotonin reuptake inhibitor - AP or TP · Sichuan Baili Pharmaceutical Co., Ltd. · Psychiatry
Selective serotonin reuptake inhibitor - BXCL501 Sublingual Film · BioXcel Therapeutics Inc · Neurology
BXCL501 is a selective serotonin reuptake inhibitor (SSRI) that modulates serotonin levels in the brain to treat acute agitation. - Clopradone · Neuroscience
Clopradone works by blocking the reabsorption of serotonin in the brain, allowing more of this neurotransmitter to be available for communication between nerve cells. - DU-176b tablets · Daiichi Sankyo Co., Ltd. · Psychiatry
DU-176b tablets are a selective serotonin reuptake inhibitor (SSRI) that works by increasing the levels of serotonin in the brain.
Patent intelligence
- selective serotonin reuptake inhibitor patent landscape — aggregated cliff calendar, attackable patents, originator estates