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Fluvoxamine+sugar pill

Guangdong Provincial People's Hospital · FDA-approved active Small molecule

Fluvoxamine selectively inhibits serotonin reuptake at the presynaptic neuron, increasing synaptic serotonin availability.

Fluvoxamine selectively inhibits serotonin reuptake at the presynaptic neuron, increasing synaptic serotonin availability. Used for Obsessive-compulsive disorder, Major depressive disorder, Social anxiety disorder.

At a glance

Generic nameFluvoxamine+sugar pill
SponsorGuangdong Provincial People's Hospital
Drug classSelective serotonin reuptake inhibitor (SSRI)
TargetSerotonin transporter (SERT)
ModalitySmall molecule
Therapeutic areaPsychiatry / Neurology
PhaseFDA-approved

Mechanism of action

Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) that blocks the serotonin transporter (SERT), preventing reuptake of serotonin from the synaptic cleft back into the presynaptic terminal. This increases serotonin concentration in the synapse, enhancing serotonergic neurotransmission. The sugar pill component is pharmacologically inert and serves as a placebo control in this formulation.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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