{"id":"fluvoxamine-sugar-pill","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Nausea"},{"rate":"15-25","effect":"Headache"},{"rate":"10-20","effect":"Insomnia"},{"rate":"10-15","effect":"Somnolence"},{"rate":"10-15","effect":"Asthenia/fatigue"},{"rate":"10-20","effect":"Sexual dysfunction"},{"rate":"5-10","effect":"Tremor"}]},"_chembl":{"chemblId":"CHEMBL814","moleculeType":"Small molecule","molecularWeight":"318.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) that blocks the serotonin transporter (SERT), preventing reuptake of serotonin from the synaptic cleft back into the presynaptic terminal. This increases serotonin concentration in the synapse, enhancing serotonergic neurotransmission. The sugar pill component is pharmacologically inert and serves as a placebo control in this formulation.","oneSentence":"Fluvoxamine selectively inhibits serotonin reuptake at the presynaptic neuron, increasing synaptic serotonin availability.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:30:41.307Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Obsessive-compulsive disorder"},{"name":"Major depressive disorder"},{"name":"Social anxiety disorder"},{"name":"Panic disorder"}]},"trialDetails":[{"nctId":"NCT02194075","phase":"PHASE4","title":"Methylphenidate Hydrochloride Controlled-Release Tablets Augmentation Strategy for Patients With Obsessive Compulsive Disorder","status":"COMPLETED","sponsor":"Guangdong Provincial People's Hospital","startDate":"2013-10","conditions":"Obsessive Compulsive Disorder","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":19659,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Fluvoxamine+sugar pill","genericName":"Fluvoxamine+sugar pill","companyName":"Guangdong Provincial People's Hospital","companyId":"guangdong-provincial-people-s-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fluvoxamine selectively inhibits serotonin reuptake at the presynaptic neuron, increasing synaptic serotonin availability. Used for Obsessive-compulsive disorder, Major depressive disorder, Social anxiety disorder.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}