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SSRI antidepressants
SSRI antidepressants is a Selective serotonin reuptake inhibitor (SSRI) Small molecule drug developed by Nanjing Medical University. It is currently FDA-approved for Major depressive disorder, Generalized anxiety disorder, Obsessive-compulsive disorder. Also known as: fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa).
SSRIs block the reuptake of serotonin at the presynaptic neuron, increasing serotonin availability in the synaptic cleft.
SSRI antidepressants are primarily used to treat conditions such as major depressive disorder, anxiety, and separation, as indicated by ClinicalTrials.gov. They work by modulating the serotonin system, specifically acting as a small molecule agonist at the melatonin receptor, as verified by ChEMBL.
At a glance
| Generic name | SSRI antidepressants |
|---|---|
| Also known as | fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), escitalopram (Lexapro) |
| Sponsor | Nanjing Medical University |
| Drug class | Selective serotonin reuptake inhibitor (SSRI) |
| Target | Serotonin transporter (SERT) |
| Modality | Small molecule |
| Therapeutic area | Psychiatry / Neurology |
| Phase | FDA-approved |
Mechanism of action
By inhibiting the serotonin transporter (SERT), SSRIs prevent the reabsorption of serotonin from the synapse back into the presynaptic terminal. This increases serotonin concentration in the synaptic space, enhancing neurotransmission and improving mood regulation. This mechanism is the basis for their efficacy in treating depression, anxiety disorders, and related conditions.
Approved indications
- Major depressive disorder
- Generalized anxiety disorder
- Obsessive-compulsive disorder
- Panic disorder
- Social anxiety disorder
- Post-traumatic stress disorder
Common side effects
- Nausea
- Headache
- Sexual dysfunction
- Insomnia
- Somnolence
- Diarrhea
- Tremor
- Dry mouth
Key clinical trials
- Study of Electrophysiological Markers of Antidepressants in Major Depressive Disorder (NA)
- Intradermal Acupuncture for Assisting SSRI Dose Reduction in Major Depressive Disorder (NA)
- SSRI Antidepressant Fluoxetine Improving Immunotherapy Efficacy in Advanced Hepatobiliary Malignancy Patients With Depression and Anxiety (PHASE2)
- Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms (PHASE3)
- A Study in Participants With Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Norepinephrine Reuptake Inhibitor (SNRI)
- Effect of Virtual Reality on Depression in Adolescent Females (NA)
- Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined Methotrexate and Antidepressant (PHASE4)
- A Study of Aticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- SSRI antidepressants CI brief — competitive landscape report
- SSRI antidepressants updates RSS · CI watch RSS
- Nanjing Medical University portfolio CI
Frequently asked questions about SSRI antidepressants
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Is SSRI antidepressants also known as anything else?
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Related
- Drug class: All Selective serotonin reuptake inhibitor (SSRI) drugs
- Target: All drugs targeting Serotonin transporter (SERT)
- Manufacturer: Nanjing Medical University — full pipeline
- Therapeutic area: All drugs in Psychiatry / Neurology
- Indication: Drugs for Major depressive disorder
- Indication: Drugs for Generalized anxiety disorder
- Indication: Drugs for Obsessive-compulsive disorder
- Also known as: fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), escitalopram (Lexapro)
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing