Last reviewed · How we verify
Major Depressive Disorder (MDD)
Approved treatments
- Edronax
- Dothiepin · All India Institute of Medical Sciences, Bhubaneswar
- Fetzima · AbbVie
Fetzima works by blocking the reabsorption of serotonin and norepinephrine in the brain, allowing more of these neurotransmitters to be available for communication between brain cells. - Rexulti · Otsuka
- Trintellix · Takeda
Vortioxetine enhances serotonergic activity through serotonin reuptake inhibition with additional 5-HT3 antagonism and 5-HT1A agonism. - Viibryd · AbbVie
- Selegiline Hydrochloride · Somerset
- Cymbalta · Eli Lilly and Company
Potentiates serotonergic and noradrenergic activity in the CNS through unknown exact mechanisms. - Thymanax · Les Laboratoires Servier
- GEPIRONE
EXXUA's antidepressant effect may stem from modulating serotonergic activity via selective agonist activity at 5HT1A receptors. - Pristiq · Pfizer
Potentiates serotonin and norepinephrine in CNS through reuptake inhibition. - Placebp · Pfizer
- Serzone · Bristol-Myers Squibb
- (+/-)-Mianserin
- Zyprexa · Eli Lilly
- Rexulti · University of Chicago
- Lexapro · Generic (originally Lundbeck/Forest)
Inhibits CNS neuronal reuptake of serotonin (5-HT), potentiating serotonergic activity. - Effexor · Generic (originally Wyeth/Pfizer)
- Prozac · RenJi Hospital
- Wellbutrin · GSK (GlaxoSmithKline)
Norepinephrine-dopamine reuptake inhibitor (NDRI) that treats depression and aids smoking cessation without serotonergic side effects. - Parnate · Par Pharmaceutical, Inc.
- Effexor · Pfizer
Potentiates serotonin and norepinephrine in CNS through reuptake inhibition. - Celexa · AbbVie
Celexa works by blocking the reabsorption of serotonin in the brain, allowing more of this neurotransmitter to be available for communication between nerve cells. - Pristiq · Alembic Pharms Ltd
Pristiq works by blocking the reabsorption of serotonin and norepinephrine in the brain, allowing more of these neurotransmitters to be available for use. - Parnate · Advanz
Parnate works by blocking an enzyme that breaks down certain neurotransmitters, allowing them to stay in the brain longer. - Desyrel · Generic (originally Angelini/Pragmaten)
Serotonin antagonist and reuptake inhibitor (SARI) that blocks 5-HT2A receptors and H1 receptors, used primarily as a sedative-hypnotic at low doses. - Delsym · Generic (originally Roche)
- Prozac · Eli Lilly and Company
Fluoxetine inhibits CNS neuronal uptake of serotonin, though exact mechanism unknown. - Remeron · Generic (originally Organon/MSD)
Noradrenergic and specific serotonergic antidepressant (NaSSA) that blocks alpha-2 adrenergic, 5-HT2, 5-HT3, and H1 receptors. - Effexor · Wyeth is now a wholly owned subsidiary of Pfizer
- Cital · Ain Shams University
- Wellbutrin · Mclean Hospital
- Zelapar · Baylor College of Medicine
- Zyprexa · Washington University School of Medicine
- Elontril · Boehringer Ingelheim
Clinical guidelines
- FDA label — 1L
Fluoxetine is indicated for the acute and maintenance treatment of Major Depressive Disorder. - FDA label — 1L
Fluoxetine is indicated for the acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD). - FDA label — 1L
Fluoxetine is indicated for the acute and maintenance treatment of binge-eating and vomiting behaviors in patients with moderate to severe Bulimia Nervosa. - FDA label — 1L
PRISTIQ is indicated for the treatment of adults with major depressive disorder (MDD). - FDA label — 1L
Sertraline hydrochloride is indicated for the treatment of major depressive disorder in adults. - FDA label — 1L
Sertraline hydrochloride is indicated for the treatment of obsessions and compulsions in patients with obsessive-compulsive disorder (OCD). - FDA label — 1L
Sertraline hydrochloride is indicated for the treatment of panic disorder. - FDA label — 1L
Sertraline hydrochloride is indicated for the treatment of posttraumatic stress disorder. - FDA label — 1L
Sertraline hydrochloride is indicated for the treatment of premenstrual dysphoric disorder. - FDA label — 1L
Sertraline hydrochloride is indicated for the treatment of social phobia. - FDA label — 1L
Duloxetine is indicated for the treatment of major depressive disorder in adults. - FDA label — 1L
Mirtazapine tablets are indicated for the treatment of major depressive disorder (MDD) in adults. - FDA label — 1L
Venlafaxine hydrochloride extended-release capsules are indicated for the treatment of adults with Major Depressive Disorder. - FDA label — 1L
Venlafaxine hydrochloride extended-release capsules are indicated for the treatment of adults with Generalized Anxiety Disorder. - FDA label — 1L
Venlafaxine hydrochloride extended-release capsules are indicated for the treatment of adults with Social Anxiety Disorder. - FDA label — 1L
Venlafaxine hydrochloride extended-release capsules are indicated for the treatment of adults with Panic Disorder. - FDA label — 1L
PRISTIQ is indicated for the treatment of adults with major depressive disorder (MDD). - FDA label — 1L
Escitalopram is indicated for the treatment of major depressive disorder (MDD) in adults and pediatric patients 12 years of age and older. - FDA label — 1L
Venlafaxine tablets, USP are indicated for the treatment of major depressive disorder.