Last reviewed · How we verify
Parnate
At a glance
| Generic name | Parnate |
|---|---|
| Also known as | Tranylcypromine |
| Sponsor | Par Pharmaceutical, Inc. |
| Target | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, Cytochrome P450 2B6, Lysine-specific histone demethylase 1B |
| Modality | Small molecule |
| Therapeutic area | Neuroscience |
| Phase | FDA-approved |
Approved indications
- Major depressive disorder
Common side effects
- Dry mouth
- Dizziness
- Insomnia
- Sedation
- Headache
- Overexcitement
- Constipation
- Blurred vision
- Tremor
- Nausea
- Diarrhea
- Abdominal pain
Serious adverse events
- Hypertensive crisis
- Suicidal thoughts and behaviors
- Serotonin syndrome
- Hepatotoxicity
- Seizures
- Agranulocytosis
- Hepatitis
- Hypomania/Mania activation
- Syncope
- SIADH
Key clinical trials
- The Effect of Tranexamic Acid in Endoscopic and Microscopic Ear Surgery Cases on Surgeon Satisfaction (NA)
- Role of Tranexamic Acid in Reducing Hemorrhagic Events in Bariatric Surgery (PHASE4)
- Comparison of the Efficacy of Misoprostol and Tranexamic Acid for Postpartum Hemorrhage Prophylaxis in Cesarean Delivery
- Comparison Effectiveness of Rectal Misoprostol & Intravenous Tranexamic Acid Reducing Hemorrhage in Myomectomy
- MAO-B Occupancy in Depressed Patients (NA)
- Efficacy of Hydroxyzine for Patients With Panic Disorder (PHASE4)
- Tranexamic Acid in Sleeve Gastrectomy (NA)
- Kaolin-based Hemostatic Gauze in Total Knee Arthroplasty (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |