Last reviewed · How we verify
Wellbutrin
At a glance
| Generic name | Wellbutrin |
|---|---|
| Also known as | bupropion, bupropion XL, Wellbutrin XL, Bupropion |
| Sponsor | Mclean Hospital |
| Target | Cytochrome P450 2C19, Neuronal acetylcholine receptor subunit alpha-7, Alpha-1A adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Metabolic |
| Phase | FDA-approved |
Approved indications
- Depressive disorder
- Major depressive disorder
- Nicotine dependence
- Obesity
- Seasonal affective disorder
- Smoking cessation assistance
Common side effects
- Dry mouth
- Nausea
- Insomnia
- Dizziness
- Pharyngitis
- Abdominal pain
- Agitation
- Anxiety
- Tremor
- Palpitation
- Sweating
- Myalgia
Serious adverse events
- Seizures
- Vomiting
- Sleep disturbances
Key clinical trials
- Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants (PHASE1)
- Pharmacological and Behavioral Treatment After Bariatric Surgery: Acute (Stage 1) (PHASE2, PHASE3)
- Preoperative Weight Loss for Open Abdominal Wall Reconstruction (NA)
- A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients (PHASE1, PHASE2)
- Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients (PHASE1)
- Pharmacokinetics Impact of HRS-8427 on Bupropion and Midazolam in Healthy Subjects (PHASE1)
- A Study to Test Whether BI 456906 (Survodutide) Influences the Amount of Bupropion, Caffeine and Midazolam in the Blood in People With Overweight or Obesity (PHASE1)
- Bupropion for Fatigue in End-stage Kidney Disease Patients on Hemodialysis (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |