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This mechanism is the basis for their efficacy in treating depression, anxiety disorders, and related conditions.","oneSentence":"SSRIs block the reuptake of serotonin at the presynaptic neuron, increasing serotonin availability in the synaptic cleft.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:09:00.204Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor","title":"Selective serotonin reuptake inhibitor","extract":"Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions."},"indications":{"approved":[{"name":"Major depressive disorder"},{"name":"Generalized anxiety disorder"},{"name":"Obsessive-compulsive disorder"},{"name":"Panic disorder"},{"name":"Social anxiety disorder"},{"name":"Post-traumatic stress 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