Last reviewed 2026-04-22 · How we verify

SSRI (SEROPLEX ou ZOLOFT)

SSRIs block the reuptake of serotonin in the brain, increasing serotonin availability in synapses to improve mood and reduce anxiety.

SSRIs block the reuptake of serotonin in the brain, increasing serotonin availability in synapses to improve mood and reduce anxiety. Used for Major depressive disorder, Generalized anxiety disorder, Panic disorder.

At a glance

Mechanism of action

Selective serotonin reuptake inhibitors (SSRIs) work by inhibiting the serotonin transporter (SERT) on presynaptic neurons, preventing the reabsorption of serotonin from the synaptic cleft. This increases serotonin concentration at the synapse, enhancing neurotransmission and producing antidepressant and anxiolytic effects. Both Seroplex (escitalopram) and Zoloft (sertraline) are commonly prescribed SSRIs with this mechanism.

Approved indications

• Major depressive disorder
• Generalized anxiety disorder
• Panic disorder
• Obsessive-compulsive disorder
• Post-traumatic stress disorder
• Social anxiety disorder

Common side effects

• Nausea
• Headache
• Sexual dysfunction
• Insomnia
• Diarrhea
• Dry mouth
• Somnolence
• Tremor

Key clinical trials

• Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression (PHASE4)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• SSRI (SEROPLEX ou ZOLOFT) CI brief — competitive landscape report
• SSRI (SEROPLEX ou ZOLOFT) updates RSS · CI watch RSS
• Centre Hospitalier Universitaire Dijon portfolio CI