{"id":"ssri-seroplex-ou-zoloft","safety":{"commonSideEffects":[{"rate":"15-25","effect":"Nausea"},{"rate":"15-20","effect":"Headache"},{"rate":"10-20","effect":"Sexual dysfunction"},{"rate":"10-15","effect":"Insomnia"},{"rate":"10-15","effect":"Diarrhea"},{"rate":"5-10","effect":"Dry mouth"},{"rate":"5-10","effect":"Somnolence"},{"rate":"5-10","effect":"Tremor"}]},"_chembl":{"chemblId":"CHEMBL520732","moleculeType":"Small molecule","molecularWeight":"512.73"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Selective serotonin reuptake inhibitors (SSRIs) work by inhibiting the serotonin transporter (SERT) on presynaptic neurons, preventing the reabsorption of serotonin from the synaptic cleft. This increases serotonin concentration at the synapse, enhancing neurotransmission and producing antidepressant and anxiolytic effects. Both Seroplex (escitalopram) and Zoloft (sertraline) are commonly prescribed SSRIs with this mechanism.","oneSentence":"SSRIs block the reuptake of serotonin in the brain, increasing serotonin availability in synapses to improve mood and reduce anxiety.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:09:00.150Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Major depressive disorder"},{"name":"Generalized anxiety disorder"},{"name":"Panic disorder"},{"name":"Obsessive-compulsive disorder"},{"name":"Post-traumatic stress disorder"},{"name":"Social anxiety disorder"}]},"trialDetails":[{"nctId":"NCT02042573","phase":"PHASE4","title":"Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression","status":"TERMINATED","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2013-11-25","conditions":"Depression","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"SSRI (SEROPLEX ou ZOLOFT)","genericName":"SSRI (SEROPLEX ou ZOLOFT)","companyName":"Centre Hospitalier Universitaire Dijon","companyId":"centre-hospitalier-universitaire-dijon","modality":"Small molecule","firstApprovalDate":"","aiSummary":"SSRIs block the reuptake of serotonin in the brain, increasing serotonin availability in synapses to improve mood and reduce anxiety. Used for Major depressive disorder, Generalized anxiety disorder, Panic disorder.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}