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sertraline fluvoxamine
sertraline fluvoxamine is a Selective serotonin reuptake inhibitor (SSRI) Small molecule drug developed by Second Affiliated Hospital, School of Medicine, Zhejiang University. It is currently FDA-approved for Depression, Anxiety disorders, Obsessive-compulsive disorder. Also known as: fluvoxamine.
This is a combination of two selective serotonin reuptake inhibitors (SSRIs) that increase synaptic serotonin by blocking its reuptake at the presynaptic membrane.
Sertraline is a small molecule used as a selective serotonin reuptake inhibitor (SSRI) in the treatment of conditions such as major depressive disorder. It is also studied in other conditions including taste disorders and geriatric depression, as well as in lactating women and their breastfed infants.
At a glance
| Generic name | sertraline fluvoxamine |
|---|---|
| Also known as | fluvoxamine |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University |
| Drug class | Selective serotonin reuptake inhibitor (SSRI) |
| Target | Serotonin transporter (SERT) |
| Modality | Small molecule |
| Therapeutic area | Psychiatry / Mental Health |
| Phase | FDA-approved |
Mechanism of action
Sertraline and fluvoxamine are both SSRIs that work by inhibiting the serotonin transporter (SERT), preventing the reuptake of serotonin from the synaptic cleft back into presynaptic neurons. This increases serotonin availability at the synapse, enhancing serotonergic neurotransmission. The combination formulation may be used to optimize therapeutic efficacy, though dual SSRI therapy is not standard clinical practice.
Approved indications
- Depression
- Anxiety disorders
- Obsessive-compulsive disorder
Common side effects
- Nausea
- Headache
- Sexual dysfunction
- Insomnia
- Diarrhea
- Tremor
Key clinical trials
- Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
- Effect of SC-ICBT for Adults With OCD：A Three-Arm Randomized Controlled Trial (NA)
- Reducing Maximal Support in OCD: Efficacy of Stepped-Care Online CBT (NA)
- Effect of a Family-Based CBT Self-Help Intervention for Adolescents With OCD (NA)
- An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression (PHASE2)
- Effect of Exercise on Tapering Antipsychotics in Patients With Psycho-cardiological Disease(EXTRA-study) (NA)
- Pragmatic Trial of Obsessive-compulsive Disorder (PHASE2)
- A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- sertraline fluvoxamine CI brief — competitive landscape report
- sertraline fluvoxamine updates RSS · CI watch RSS
- Second Affiliated Hospital, School of Medicine, Zhejiang University portfolio CI
Frequently asked questions about sertraline fluvoxamine
What is sertraline fluvoxamine?
How does sertraline fluvoxamine work?
What is sertraline fluvoxamine used for?
Who makes sertraline fluvoxamine?
Is sertraline fluvoxamine also known as anything else?
What drug class is sertraline fluvoxamine in?
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What are the side effects of sertraline fluvoxamine?
What does sertraline fluvoxamine target?
Related
- Drug class: All Selective serotonin reuptake inhibitor (SSRI) drugs
- Target: All drugs targeting Serotonin transporter (SERT)
- Manufacturer: Second Affiliated Hospital, School of Medicine, Zhejiang University — full pipeline
- Therapeutic area: All drugs in Psychiatry / Mental Health
- Indication: Drugs for Depression
- Indication: Drugs for Anxiety disorders
- Indication: Drugs for Obsessive-compulsive disorder
- Also known as: fluvoxamine
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing