Long-acting basal insulin

This page covers all Long-acting basal insulin drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Insulin receptor, Insulin receptor (glargine); GLP-1 receptor (exenatide), DPP-4 enzyme, metformin (AMPK pathway), insulin receptor (Lantus).

Targets

Insulin receptor · Insulin receptor (glargine); GLP-1 receptor (exenatide) · DPP-4 enzyme, metformin (AMPK pathway), insulin receptor (Lantus) · GLP-1 receptor; insulin receptor · Insulin receptor (degludec); GLP-1 receptor (liraglutide) · Multiple: AMP-activated protein kinase (metformin), ATP-sensitive potassium channels (glyburide), insulin receptor (glargine) · Insulin receptor (basal insulin); GLP-1 receptor (exenatide) · GLP-1R · DPP-4 (dipeptidyl peptidase-4) and insulin receptor

Marketed (36)

• Insulin degludec, 100U/ml · Sanofi · Diabetes
  Insulin degludec is a long-acting basal insulin that binds to the insulin receptor to promote glucose uptake and utilization in peripheral tissues while suppressing hepatic glucose production.
• Detemir insulin · The University of Texas Health Science Center, Houston · Diabetes
  Detemir insulin is a long-acting basal insulin that binds to the insulin receptor to lower blood glucose by promoting glucose uptake and storage in cells.
• INSULIN GLARGINE HOE 901 · Sanofi · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and lower blood glucose levels.
• glargine + exenatide · Huazhong University of Science and Technology · Diabetes
  This combination pairs a long-acting basal insulin (glargine) with a GLP-1 receptor agonist (exenatide) to lower blood glucose through both insulin replacement and incretin-mimetic pathways.
• Insulin glargine, 100 U/ml · Sanofi · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and utilization while suppressing hepatic glucose production.
• insulin glargine [rDNA origin] injection · Sanofi · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.
• Insulin Degludec 100 UNT/ML [Tresiba] · Merete Bechmann Christensen · Diabetes
  Insulin degludec is a long-acting basal insulin that binds to the insulin receptor to promote glucose uptake and utilization in peripheral tissues while suppressing hepatic glucose production.
• Janumet, Lantus · Chinese University of Hong Kong · Diabetes
  Janumet combines sitagliptin (a DPP-4 inhibitor) with metformin to lower blood glucose by increasing incretin levels and reducing hepatic glucose production, while Lantus is a long-acting basal insulin that provides steady glucose control.
• NPH insulin · Novo Nordisk A/S · Diabetes
  NPH insulin is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.
• Tresiba® · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Diabetes
  Tresiba is a long-acting basal insulin analog that binds to the insulin receptor to lower blood glucose by promoting glucose uptake and storage in peripheral tissues.
• Early Glargine · The Cleveland Clinic · Diabetes
  Early Glargine is a long-acting basal insulin analog that binds to the insulin receptor to lower blood glucose by promoting glucose uptake and storage in peripheral tissues.
• Basal Insulin Analog · Eli Lilly and Company · Diabetes
  Basal insulin analogs mimic the body's natural background insulin secretion by binding to insulin receptors and promoting glucose uptake into cells.
• Glargine U300 · University of Split, School of Medicine · Diabetes
  Glargine U300 is a long-acting basal insulin that binds to insulin receptors to promote glucose uptake and utilization in peripheral tissues while suppressing hepatic glucose production.
• Insulin Glargine 100 UNT/ML · University Hospital Tuebingen · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and reduce blood glucose levels.
• Gla-100 (insulin glargine) · Sanofi · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and reduce blood glucose levels.
• Insulin degludec 100 U/mL · Sanofi · Diabetes
  Insulin degludec is a long-acting basal insulin that binds to the insulin receptor to promote glucose uptake and utilization in peripheral tissues while suppressing hepatic glucose production.
• Basalin to Lantus · Nanjing First Hospital, Nanjing Medical University · Diabetes
  Basalin is a long-acting basal insulin analog that binds to insulin receptors to lower blood glucose by promoting glucose uptake and storage in peripheral tissues.
• Continuation of insulin glargine · Providence Health & Services · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake into cells and inhibiting hepatic glucose production.
• Insulin Detemir mixed with RAI injection · Montefiore Medical Center · Diabetes
  Insulin detemir provides basal insulin replacement by binding to the insulin receptor, while RAI (radioactive iodine) component is unclear in this context as RAI is typically used for thyroid ablation, not diabetes management.
• Levemir (insulin detemir) · Rabin Medical Center · Diabetes
  Insulin detemir is a long-acting basal insulin that binds to the insulin receptor to lower blood glucose by promoting glucose uptake and storage in peripheral tissues while suppressing hepatic glucose production.
• Insulin-Levemir · Novo Nordisk A/S · Diabetes
  Insulin detemir is a long-acting basal insulin that binds to the insulin receptor to facilitate glucose uptake and utilization in peripheral tissues while suppressing hepatic glucose production.
• Insulin glargine 300 U/ml · Sanofi · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.
• Insulin glargine (U300) · Sanofi · Diabetes
  Insulin glargine (U300) is a long-acting basal insulin that binds to insulin receptors on muscle and fat cells to promote glucose uptake and reduce blood glucose levels.
• Detemir or Glargine · Institut de Recherches Cliniques de Montreal · Diabetes
  Detemir and Glargine are long-acting basal insulin analogs that bind to the insulin receptor to lower blood glucose by promoting glucose uptake and storage in peripheral tissues.
• Insulin glargine, 300U/mL · Sanofi · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and reduce blood glucose levels.
• Insulin glargine (HOE901) · Sanofi · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and reduce blood glucose levels.
• lixisenatide + glargine · Medical University of Warsaw · Diabetes
  Lixisenatide stimulates insulin secretion via GLP-1 receptor agonism, while glargine provides basal insulin coverage, together improving glycemic control in type 2 diabetes.
• Toujeo SoloStar · Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud · Diabetes
  Toujeo SoloStar is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake and storage in cells.
• biosimilar insulin glargine · Life for a Child Program, Diabetes Australia · Diabetes
  Biosimilar insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and lower blood glucose levels.
• IGlar U100 · Novo Nordisk A/S · Diabetes
  IGlar U100 is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake and storage in peripheral tissues.
• switch NPH to glargin · Les Laboratoires des Médicaments Stériles · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake and storage in peripheral tissues and suppressing hepatic glucose production.
• Insulin glargine U100 · Novo Nordisk A/S · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and reduce blood glucose levels.
• insulin degludec + liraglutide · Hospital Universitario San Ignacio · Diabetes
  This combination provides basal insulin coverage via degludec while enhancing glucose-dependent insulin secretion and reducing appetite through liraglutide's GLP-1 receptor agonism.
• metformin, glyburide and glargine · The University of Texas Health Science Center at San Antonio · Diabetes
  This combination therapy addresses type 2 diabetes through three complementary mechanisms: metformin reduces hepatic glucose production, glyburide stimulates pancreatic insulin secretion, and glargine provides basal insulin coverage.
• Basal insulin analogues · Novo Nordisk A/S · Diabetes
  Basal insulin analogues are long-acting insulin formulations that bind to insulin receptors to promote glucose uptake and utilization, providing steady background insulin coverage for blood glucose control.
• Insulin Lispro Protamine Suspension · Eli Lilly and Company · Diabetes
  Insulin lispro protamine suspension is a long-acting basal insulin that binds to insulin receptors on muscle and fat cells to promote glucose uptake and storage, lowering blood glucose levels.

Phase 3 pipeline (15)

• Basal insulin and exenatide · Mount Sinai Hospital, Canada · Diabetes
  This combination uses basal insulin to provide background glucose control while exenatide stimulates insulin secretion and slows gastric emptying in response to meals.
• GZR18 · Gan & Lee Pharmaceuticals. · Diabetes
  GZR18 is a long-acting basal insulin analog designed to provide sustained glucose control in diabetes.
• Lantus (glargine) · Massachusetts General Hospital · Diabetes
  Lantus is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake and storage in cells.
• Insulin Degludec Injection · Jiangsu HengRui Medicine Co., Ltd. · Diabetes
  Insulin degludec is a long-acting basal insulin that binds to the insulin receptor to promote glucose uptake and utilization in peripheral tissues while suppressing hepatic glucose production.
• Once-daily insulin detemir · Sydney Children's Hospitals Network · Diabetes
  Insulin detemir is a long-acting basal insulin that binds to the insulin receptor to lower blood glucose by promoting glucose uptake and storage in peripheral tissues while suppressing hepatic glucose production.
• albiglutide + insulin glargine · GlaxoSmithKline · Diabetes
  Albiglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that enhances glucose-dependent insulin secretion, and insulin glargine is a long-acting basal insulin analog that provides a steady level of insulin throughout the day.
• Linagliptin and Basal Insulin · Rabin Medical Center · Diabetes
  Linagliptin inhibits dipeptidyl peptidase-4 (DPP-4) to increase incretin levels and improve glycemic control, while basal insulin provides long-acting glucose lowering.
• Insulin Glargine Rescue Medication · Merck Sharp & Dohme LLC · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake and storage in peripheral tissues while suppressing hepatic glucose production.
• LY2605541 · Eli Lilly and Company · Diabetes
  LY2605541 is a long-acting basal insulin analog that binds to the insulin receptor to lower blood glucose levels in diabetes.
• Insulin Glargine 100U/mL · Novo Nordisk A/S · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors on cells to promote glucose uptake and reduce blood glucose levels.
• Lantus (insulin glargine) · Sanofi · Diabetes
  Lantus is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake into cells and inhibiting hepatic glucose production.
• Gan & Lee Insulin Glargine Injection · Gan and Lee Pharmaceuticals, USA · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to insulin receptors to lower blood glucose by promoting glucose uptake and storage in peripheral tissues and suppressing hepatic glucose production.
• LY2963016 · Eli Lilly and Company · Diabetes
  LY2963016 is a long-acting basal insulin analog that binds to the insulin receptor to regulate blood glucose by promoting glucose uptake and storage.
• Insulin glargine U100 (HOE901) · Sanofi · Diabetes
  Insulin glargine is a long-acting basal insulin that binds to the insulin receptor to promote glucose uptake and utilization in peripheral tissues while suppressing hepatic glucose production.
• Placebo insulin icodec · Novo Nordisk A/S · Diabetes
  Insulin icodec is a long-acting basal insulin analog that binds to the insulin receptor to regulate blood glucose by promoting glucose uptake and storage.

Patent intelligence

• basal insulin patent landscape — aggregated cliff calendar, attackable patents, originator estates