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albiglutide + insulin glargine
albiglutide + insulin glargine is a GLP-1 receptor agonist and long-acting basal insulin analog Biologic drug developed by GlaxoSmithKline. It is currently in Phase 3 development for Type 2 diabetes mellitus, Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Albiglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that enhances glucose-dependent insulin secretion, and insulin glargine is a long-acting basal insulin analog that provides a steady level of insulin throughout the day.
Albiglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that enhances glucose-dependent insulin secretion, and insulin glargine is a long-acting basal insulin analog that provides a steady level of insulin throughout the day. Used for Type 2 diabetes mellitus, Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
At a glance
| Generic name | albiglutide + insulin glargine |
|---|---|
| Sponsor | GlaxoSmithKline |
| Drug class | GLP-1 receptor agonist and long-acting basal insulin analog |
| Target | GLP-1R |
| Modality | Biologic |
| Therapeutic area | Diabetes |
| Phase | Phase 3 |
Mechanism of action
Albiglutide works by binding to GLP-1 receptors in the pancreas, stimulating insulin release in response to elevated glucose levels. Insulin glargine, on the other hand, is a modified form of human insulin that is designed to be released slowly and steadily over a 24-hour period, providing a basal level of insulin to help control blood sugar levels.
Approved indications
- Type 2 diabetes mellitus
- Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
Common side effects
- Nausea
- Injection site reactions
- Diarrhea
- Abdominal pain
- Headache
- Fatigue
- Muscle pain
- Dizziness
- Nasopharyngitis
- Upper respiratory tract infection
Key clinical trials
- Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study
- Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes, With a FRC Extension Period (PHASE3)
- Safety and Efficacy of Albiglutide + Insulin Glargine Versus Insulin Lispro + Insulin Glargine Subjects With Type 2 Diabetes Mellitus (PHASE3)
- Stepping-down Approach in Patients With Chronic Poorly-controlled Diabetes on Advanced Insulin Therapy? (NA)
- A Study to Determine the Safety and Efficacy of Albiglutide Administered in Combination With Insulin Glargine (PHASE3)
- A Study to Determine the Safety and Efficacy of Albiglutide in Patients With Type 2 Diabetes (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- albiglutide + insulin glargine CI brief — competitive landscape report
- albiglutide + insulin glargine updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI
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Related
- Drug class: All GLP-1 receptor agonist and long-acting basal insulin analog drugs
- Target: All drugs targeting GLP-1R
- Manufacturer: GlaxoSmithKline — full pipeline
- Therapeutic area: All drugs in Diabetes
- Indication: Drugs for Type 2 diabetes mellitus
- Indication: Drugs for Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
- Compare: albiglutide + insulin glargine vs similar drugs
- Pricing: albiglutide + insulin glargine cost, discount & access