What are ACE inhibitor drugs?

ACE inhibitor drugs are pharmacologic agents that share a common mechanism (typically targeting Angiotensin-converting enzyme (ACE)). 14 are currently marketed, with 25 more in clinical development.

What are the marketed ACE inhibitor drugs?

Marketed ACE inhibitor drugs include Perindopril tablet, Captopril and Trandolapril, Optimal Medical treatment, Oral Captopril, ACE inhibitor, ACEI treatment.

ACE inhibitor

14 marketed 20 in Phase 3 5 in Phase 2

This page covers all ACE inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Angiotensin-converting enzyme (ACE), Angiotensin II receptor, Angiotensin-converting enzyme, Angiotensin-converting enzyme.

Targets

Angiotensin-converting enzyme (ACE) · Angiotensin II receptor · Angiotensin-converting enzyme, Angiotensin-converting enzyme · ACE · AT1 receptor

Marketed (14)

Perindopril tablet · Pharmtechnology LLC · Cardiovascular
Perindopril inhibits angiotensin-converting enzyme (ACE), reducing the formation of angiotensin II and lowering blood pressure.
Captopril and Trandolapril · Rigshospitalet, Denmark · Cardiovascular
Both captopril and trandolapril inhibit angiotensin-converting enzyme (ACE), reducing the formation of angiotensin II and lowering blood pressure.
Optimal Medical treatment · Seung-Jung Park · Cardiovascular
Optimal Medical treatment works by inhibiting the renin-angiotensin system to lower blood pressure.
Oral Captopril · Ain Shams University · Cardiovascular
Captopril inhibits angiotensin-converting enzyme (ACE), reducing the formation of angiotensin II and lowering blood pressure.
ACE inhibitor · University of Cambridge · Cardiovascular
ACE inhibitors block the angiotensin-converting enzyme, preventing the conversion of angiotensin I to angiotensin II and thereby reducing vasoconstriction and aldosterone release.
ACEI treatment · Children's Hospital of Fudan University · Cardiovascular
ACE inhibitors block the angiotensin-converting enzyme, reducing the production of angiotensin II and lowering blood pressure.
ACE Reno · Ace Cells Lab Limited · Cardiovascular
ACE Reno is an angiotensin-converting enzyme (ACE) inhibitor that works by relaxing blood vessels and reducing blood pressure.
Ramipril (ACE-inhibitor) · National Heart Institute, Egypt · Cardiovascular
Ramipril inhibits angiotensin-converting enzyme (ACE), reducing the conversion of angiotensin I to angiotensin II and thereby lowering blood pressure and reducing cardiac workload.
Perindopril (T1) · Hospices Civils de Lyon · Cardiovascular
Perindopril inhibits angiotensin-converting enzyme (ACE), reducing the formation of angiotensin II and lowering blood pressure.
Captopril Tablets · Ain Shams University · Cardiovascular
Captopril inhibits angiotensin-converting enzyme (ACE), reducing the formation of angiotensin II and lowering blood pressure.
RAMIPRIL HOE498 · Sanofi · Cardiovascular
Ramipril inhibits angiotensin-converting enzyme (ACE), reducing the formation of angiotensin II and lowering blood pressure.
ACE inhibitors · GlaxoSmithKline · Cardiovascular
ACE inhibitors block the angiotensin-converting enzyme, preventing the conversion of angiotensin I to angiotensin II and thereby reducing vasoconstriction and aldosterone release.
Vasotec · Merck & Co. · Cardiovascular
ACE inhibitor prodrug that is converted to enalaprilat, blocking angiotensin-converting enzyme to lower blood pressure.
ACEI continuation · University of Nebraska · Cardiovascular
ACEI continuation refers to the ongoing use of angiotensin-converting enzyme inhibitors to block the conversion of angiotensin I to angiotensin II, thereby reducing vasoconstriction and lowering blood pressure.

Phase 3 pipeline (20)

BR1018A-1 · Boryung Pharmaceutical Co., Ltd · Cardiovascular
BR1018A-1 is a small molecule drug that targets the renin-angiotensin system.
RBT-1 · Renibus Therapeutics, Inc. · Cardiovascular
RBT-1 is a small molecule that targets the renin-angiotensin system to treat hypertension.
a simulated agent of Jitongning tablets · Tasly Pharmaceutical Group Co., Ltd · Cardiovascular
Jitongning tablets are a simulated agent that works by inhibiting the renin-angiotensin-aldosterone system (RAAS) to lower blood pressure.
BR1018C-1 · Boryung Pharmaceutical Co., Ltd · Cardiovascular
BR1018C-1 is a small molecule that targets the renin-angiotensin system.
BP101 · Ivix LLX · Cardiovascular
BP101 is a small molecule that targets the renin-angiotensin system to lower blood pressure.
ACE inhibitor Ramipril · Mario Negri Institute for Pharmacological Research · Cardiovascular
Ramipril inhibits angiotensin-converting enzyme (ACE), reducing the conversion of angiotensin I to angiotensin II and thereby lowering blood pressure and reducing cardiac workload.
Standard of Care IV antihypertensive · The Medicines Company · Cardiovascular
Blocks the action of angiotensin II at its receptor, leading to vasodilation and decreased blood pressure.
VGR-R01 · Shanghai Vitalgen BioPharma Co., Ltd. · Cardiovascular
VGR-R01 is a small molecule drug that targets the renin-angiotensin system.
DW-330SR2 · Daewon Pharmaceutical Co., Ltd. · Cardiovascular
DW-330SR2 is a small molecule that targets the renin-angiotensin system.
BR1019A-1 · Boryung Pharmaceutical Co., Ltd · Cardiovascular
BR1019A-1 is a small molecule that targets the renin-angiotensin system.
GP40071 · Geropharm · Cardiovascular
GP40071 is a small molecule drug that targets the renin-angiotensin system.
NPF-08 （2-day split dose） · Nihon Pharmaceutical Co., Ltd · Cardiovascular
NPF-08 is a small molecule that targets the renin-angiotensin system to lower blood pressure.
Product CM9241GRU · Ache Laboratorios Farmaceuticos S.A. · Cardiovascular
CM9241GRU is a drug that targets the renin-angiotensin system.
Inhibitors, ACE · National Heart, Lung, and Blood Institute (NHLBI) · Cardiovascular
ACE inhibitors block the angiotensin-converting enzyme, preventing the conversion of angiotensin I to angiotensin II and thereby reducing vasoconstriction and aldosterone release.
BR1019C-1 · Boryung Pharmaceutical Co., Ltd · Cardiovascular
BR1019C-1 is a small molecule drug that targets the renin-angiotensin system.
Perindopril or Perindopril/Indapamide · Boryung Pharmaceutical Co., Ltd · Cardiovascular
Perindopril is an angiotensin-converting enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II, thereby reducing blood pressure and heart workload.
AG NPP709syrup · Ahn-Gook Pharmaceuticals Co.,Ltd · Cardiovascular
AG NPP709 syrup is a medication that targets the renin-angiotensin system to treat hypertension.
T-2345 · Nephron Pharmaceuticals Corporation · Cardiovascular
T-2345 is a small molecule drug that targets the renin-angiotensin system.
TDI01 suspension · Beijing Tide Pharmaceutical Co., Ltd · Cardiovascular
TDI01 suspension is a medication that targets the renin-angiotensin-aldosterone system (RAAS) to treat hypertension.
BPDO-1603 · Hyundai Pharmaceutical Co., LTD. · Cardiovascular
BPDO-1603 is a small molecule that targets the renin-angiotensin system to lower blood pressure.

Phase 2 pipeline (5)

BP1.3656 low dose · Bioprojet · Cardiovascular
BP1.3656 low dose is a medication that lowers blood pressure by acting on the renin-angiotensin system.
Enalapril Orodispersible Minitablet · Ethicare GmbH · Cardiovascular
Enalapril inhibits angiotensin-converting enzyme (ACE), reducing the production of angiotensin II and aldosterone, leading to vasodilation and decreased blood pressure.
BP-C2 · Meddoc · Cardiovascular
BP-C2 is a small molecule that targets the renin-angiotensin system to lower blood pressure.
H001 Capsule 200mg-qd · Livzon Pharmaceutical Group Inc. · Cardiovascular
H001 Capsule 200mg-qd is a medication that targets the renin-angiotensin system to lower blood pressure.
BP1.4979 active drug · Bioprojet · Cardiovascular
BP1.4979 is a small molecule drug that targets the renin-angiotensin system.