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Standard of Care IV antihypertensive

The Medicines Company · Phase 3 active Small molecule

Standard of Care IV antihypertensive is a ACE inhibitor Small molecule drug developed by The Medicines Company. It is currently in Phase 3 development for Hypertension. Also known as: nitroglycerin, nicardipine, sodium nitroprusside, isosorbide dinitrate.

Blocks the action of angiotensin II at its receptor, leading to vasodilation and decreased blood pressure.

Blocks the action of angiotensin II at its receptor, leading to vasodilation and decreased blood pressure. Used for Hypertension.

At a glance

Generic nameStandard of Care IV antihypertensive
Also known asnitroglycerin, nicardipine, sodium nitroprusside, isosorbide dinitrate, hydralizine
SponsorThe Medicines Company
Drug classACE inhibitor
TargetAT1 receptor
ModalitySmall molecule
Therapeutic areaCardiovascular
PhasePhase 3

Mechanism of action

This is achieved through the inhibition of the angiotensin II type 1 receptor, which is a key component of the renin-angiotensin-aldosterone system. By blocking this receptor, the drug reduces the vasoconstrictive and aldosterone-secreting effects of angiotensin II, resulting in decreased blood pressure and reduced strain on the heart.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Standard of Care IV antihypertensive

What is Standard of Care IV antihypertensive?

Standard of Care IV antihypertensive is a ACE inhibitor drug developed by The Medicines Company, indicated for Hypertension.

How does Standard of Care IV antihypertensive work?

Blocks the action of angiotensin II at its receptor, leading to vasodilation and decreased blood pressure.

What is Standard of Care IV antihypertensive used for?

Standard of Care IV antihypertensive is indicated for Hypertension.

Who makes Standard of Care IV antihypertensive?

Standard of Care IV antihypertensive is developed by The Medicines Company (see full The Medicines Company pipeline at /company/the-medicines-company).

Is Standard of Care IV antihypertensive also known as anything else?

Standard of Care IV antihypertensive is also known as nitroglycerin, nicardipine, sodium nitroprusside, isosorbide dinitrate, hydralizine.

What drug class is Standard of Care IV antihypertensive in?

Standard of Care IV antihypertensive belongs to the ACE inhibitor class. See all ACE inhibitor drugs at /class/ace-inhibitor.

What development phase is Standard of Care IV antihypertensive in?

Standard of Care IV antihypertensive is in Phase 3.

What are the side effects of Standard of Care IV antihypertensive?

Common side effects of Standard of Care IV antihypertensive include Cough, Dizziness, Headache.

What does Standard of Care IV antihypertensive target?

Standard of Care IV antihypertensive targets AT1 receptor and is a ACE inhibitor.

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